Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   MPG48_RS04595 Genome accession   NZ_CP094113
Coordinates   969115..970899 (+) Length   594 a.a.
NCBI ID   WP_245064733.1    Uniprot ID   -
Organism   Helicobacter pylori strain Hpfe069     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 964115..975899
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MPG48_RS04565 (MPG48_04565) motB 964777..965544 (+) 768 WP_245015826.1 flagellar motor protein MotB -
  MPG48_RS04570 (MPG48_04570) - 965548..965985 (+) 438 WP_001031792.1 hypothetical protein -
  MPG48_RS04575 (MPG48_04575) - 966166..967827 (+) 1662 WP_245064731.1 ABC transporter permease/substrate-binding protein -
  MPG48_RS04580 (MPG48_04580) - 967829..968470 (+) 642 WP_245064732.1 ATP-binding cassette domain-containing protein -
  MPG48_RS04585 (MPG48_04585) - 968482..968661 (-) 180 WP_000468796.1 hypothetical protein -
  MPG48_RS04590 (MPG48_04590) - 968653..969114 (+) 462 WP_000437188.1 hypothetical protein -
  MPG48_RS04595 (MPG48_04595) uvrC 969115..970899 (+) 1785 WP_245064733.1 excinuclease ABC subunit UvrC Machinery gene
  MPG48_RS04600 (MPG48_04600) - 970910..972175 (+) 1266 WP_245064734.1 homoserine dehydrogenase -
  MPG48_RS04605 (MPG48_04605) - 972176..972520 (+) 345 WP_180450246.1 YraN family protein -
  MPG48_RS04610 (MPG48_04610) trxA 972609..972929 (+) 321 WP_000020200.1 thioredoxin -
  MPG48_RS04615 (MPG48_04615) trxB 972935..973870 (+) 936 WP_245064735.1 thioredoxin-disulfide reductase -
  MPG48_RS04620 (MPG48_04620) - 974037..974858 (+) 822 WP_245064736.1 glycosyltransferase family 25 protein -
  MPG48_RS04625 (MPG48_04625) - 975056..975304 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68851.14 Da        Isoelectric Point: 9.5817

>NTDB_id=667032 MPG48_RS04595 WP_245064733.1 969115..970899(+) (uvrC) [Helicobacter pylori strain Hpfe069]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIRSYFSIHNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGSNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFIFHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEVRSLFKLECMPYRVEIFDT
SHHANSQCVGGMVVYENHEFQKNSYRRYHLKGSNEYTQMSELLTRRALDFNKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTASDTFKLLPSDKCLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=667032 MPG48_RS04595 WP_245064733.1 969115..970899(+) (uvrC) [Helicobacter pylori strain Hpfe069]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAGAAGCTATTTTTCTATCCACAATAATGAAATCACGCCCA
ATCATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTAGAAAACGAACAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAACAGCTCAAGCCCAAATACAACATTCTTTTAAGAGATGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAAGATATTTTAGACAGCTTGTATGAATTGCTTCCGTTAGTTCAAAAGAAA
AATTGCATCAAAGACAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTGAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCTCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCTATTATCAATCATTACCAATCGCATTTGCCTTTAATGCCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTTTCATCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGTGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTAGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTAATAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCACACCGCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAGTGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.97

100

0.97

Multiple sequence alignment