Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   MPG14_RS03910 Genome accession   NZ_CP094102
Coordinates   822017..823801 (+) Length   594 a.a.
NCBI ID   WP_245053249.1    Uniprot ID   -
Organism   Helicobacter pylori strain Hpfe078     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 817017..828801
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MPG14_RS03875 (MPG14_03875) - 817066..817297 (+) 232 Protein_772 osmoprotection protein -
  MPG14_RS03880 (MPG14_03880) - 817322..817894 (-) 573 WP_021300186.1 Hpy99I family type II restriction endonuclease -
  MPG14_RS03885 (MPG14_03885) - 817888..818706 (-) 819 WP_089482685.1 site-specific DNA-methyltransferase -
  MPG14_RS03890 (MPG14_03890) - 819066..820727 (+) 1662 WP_245053245.1 ABC transporter permease/substrate-binding protein -
  MPG14_RS03895 (MPG14_03895) - 820731..821372 (+) 642 WP_245053247.1 ATP-binding cassette domain-containing protein -
  MPG14_RS03900 (MPG14_03900) - 821384..821563 (-) 180 WP_000468796.1 hypothetical protein -
  MPG14_RS03905 (MPG14_03905) - 821555..822016 (+) 462 WP_000437191.1 hypothetical protein -
  MPG14_RS03910 (MPG14_03910) uvrC 822017..823801 (+) 1785 WP_245053249.1 excinuclease ABC subunit UvrC Machinery gene
  MPG14_RS03915 (MPG14_03915) - 823812..825077 (+) 1266 WP_245053251.1 homoserine dehydrogenase -
  MPG14_RS03920 (MPG14_03920) - 825078..825422 (+) 345 WP_245053253.1 YraN family protein -
  MPG14_RS03925 (MPG14_03925) trxA 825511..825831 (+) 321 WP_000020199.1 thioredoxin -
  MPG14_RS03930 (MPG14_03930) trxB 825837..826772 (+) 936 WP_096528296.1 thioredoxin-disulfide reductase -
  MPG14_RS03935 (MPG14_03935) - 826939..827760 (+) 822 WP_245053255.1 glycosyltransferase family 25 protein -
  MPG14_RS03940 (MPG14_03940) - 827957..828205 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68784.97 Da        Isoelectric Point: 9.5667

>NTDB_id=666876 MPG14_RS03910 WP_245053249.1 822017..823801(+) (uvrC) [Helicobacter pylori strain Hpfe078]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNYRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIEGKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGSNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIIDHYQSHLPLMPEQILLN
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHANSQCVGGMVVYENHEFQKNSYRRYHLKGSNEYTQMSELLTRRALDFNKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTANDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=666876 MPG14_RS03910 WP_245053249.1 822017..823801(+) (uvrC) [Helicobacter pylori strain Hpfe078]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAATAATGAAATCACGCCCA
ATTATCGTGCAAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAAGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCGAAGGTAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CTGATGAAGCAATGAAACAAGCCATTATCGATCATTACCAATCGCATTTGCCTTTAATGCCAGAACAAATCTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAGTTTATCTCCCACCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCCTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTAATAAAGAGC
CGCCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATCAT
CCACACCGCTAACGATACTTTTAAATTGCTCCCTAGCGACAAGCGTTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAGGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.801

100

0.968