Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   MPG32_RS02590 Genome accession   NZ_CP094073
Coordinates   572962..574746 (+) Length   594 a.a.
NCBI ID   WP_245037316.1    Uniprot ID   -
Organism   Helicobacter pylori strain Hpfe104     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 567962..579746
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MPG32_RS02555 (MPG32_02555) - 568004..568257 (+) 254 Protein_501 osmoprotection protein -
  MPG32_RS02560 (MPG32_02560) - 568269..568841 (-) 573 WP_245019238.1 Hpy99I family type II restriction endonuclease -
  MPG32_RS02565 (MPG32_02565) - 568835..569653 (-) 819 WP_089482685.1 site-specific DNA-methyltransferase -
  MPG32_RS02570 (MPG32_02570) - 570013..571674 (+) 1662 WP_245037312.1 ABC transporter permease/substrate-binding protein -
  MPG32_RS02575 (MPG32_02575) - 571676..572317 (+) 642 WP_245037314.1 ABC transporter ATP-binding protein -
  MPG32_RS02580 (MPG32_02580) - 572329..572508 (-) 180 WP_000468796.1 hypothetical protein -
  MPG32_RS02585 (MPG32_02585) - 572500..572961 (+) 462 WP_000437191.1 hypothetical protein -
  MPG32_RS02590 (MPG32_02590) uvrC 572962..574746 (+) 1785 WP_245037316.1 excinuclease ABC subunit UvrC Machinery gene
  MPG32_RS02595 (MPG32_02595) - 574757..576022 (+) 1266 WP_000746788.1 homoserine dehydrogenase -
  MPG32_RS02600 (MPG32_02600) - 576023..576367 (+) 345 WP_033587184.1 YraN family protein -
  MPG32_RS02605 (MPG32_02605) trxA 576456..576776 (+) 321 WP_000020199.1 thioredoxin -
  MPG32_RS02610 (MPG32_02610) trxB 576782..577717 (+) 936 WP_021307556.1 thioredoxin-disulfide reductase -
  MPG32_RS02615 (MPG32_02615) - 577884..578705 (+) 822 WP_245037318.1 glycosyltransferase family 25 protein -
  MPG32_RS02620 (MPG32_02620) - 578909..579157 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68702.93 Da        Isoelectric Point: 9.5818

>NTDB_id=666433 MPG32_RS02590 WP_245037316.1 572962..574746(+) (uvrC) [Helicobacter pylori strain Hpfe104]
MADLLSSLKNLSHSSGVYQYFDKNCQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGSNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQDFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFQLECMPYRVEIFDT
SHHANSQCVGGMVVYENHEFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=666433 MPG32_RS02590 WP_245037316.1 572962..574746(+) (uvrC) [Helicobacter pylori strain Hpfe104]
ATGGCTGATTTATTGTCTAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACTGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCTATCCACAATAATGAAATCACGCCCA
ATCATCGTGCAAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTAGAAAACGAACAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGATGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAAGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGCTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATAGTGGGAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGATTTTATCTCTCACCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTCAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCCTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACTAGAAGGGCTTTAGATTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGAGGTGCTAAAGACATTAT
CCACACGCCTAGTAATACTTTTAAATTGCTCCCTAGCGACAAGCGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.306

100

0.973