Detailed information NTG0665963

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: MO978_RS11635
• Genome accession: NZ_CP093959
• Coordinates: 2291519..2292547 (-)
• Length: 342 a.a.
• NCBI ID: WP_003132657.1
• Uniprot ID: S6FVM6
• Organism: Lactococcus lactis strain FAM 17919
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2286519..2297547

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MO978_RS11610 (MO978_11595)	-	2286805..2287302 (-)	498	WP_003132662.1	nitroreductase family protein	-
MO978_RS11615 (MO978_11600)	-	2287289..2287498 (-)	210	WP_003132661.1	hypothetical protein	-
MO978_RS11620 (MO978_11605)	-	2287495..2288322 (-)	828	WP_058221368.1	radical SAM protein	-
MO978_RS11625 (MO978_11610)	-	2288315..2290438 (-)	2124	WP_003132659.1	radical SAM protein	-
MO978_RS11630 (MO978_11615)	-	2290541..2291398 (-)	858	WP_003132658.1	Rgg/GadR/MutR family transcriptional regulator	-
MO978_RS11635 (MO978_11620)	sepM	2291519..2292547 (-)	1029	WP_003132657.1	SepM family pheromone-processing serine protease	Regulator
MO978_RS11640 (MO978_11625)	coaD	2292534..2293031 (-)	498	WP_010906348.1	pantetheine-phosphate adenylyltransferase	-
MO978_RS11645 (MO978_11630)	rsmD	2293079..2293618 (-)	540	WP_373961914.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
MO978_RS11650 (MO978_11635)	-	2293789..2295009 (-)	1221	WP_003132654.1	MFS transporter	-
MO978_RS11655 (MO978_11640)	lmrP	2295093..2296318 (-)	1226	Protein_2264	multidrug efflux MFS transporter LmrP	-
MO978_RS11660 (MO978_11645)	-	2296506..2297000 (+)	495	WP_012898649.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 342 a.a.
• Molecular weight: 37349.96 Da
• Isoelectric Point: 9.9183

>NTDB_id=665963 MO978_RS11635 WP_003132657.1 2291519..2292547(-) (sepM) [Lactococcus lactis strain FAM 17919]
MKKNKKINPKLKWGISIGLIVVALLALFYPTSYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYSH
FNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAIYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELADTITAV
NGQQFTSSADMIAYVSKQKVGDSVTIEYTRIDGTKHKSTGKYIKIANGKTGIGISLVDHTEVVTTPKVTVNAGSIGGPSA
GMMFTLEIYSQLTGKDLRNGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAKK
LKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1029 bp

>NTDB_id=665963 MO978_RS11635 WP_003132657.1 2291519..2292547(-) (sepM) [Lactococcus lactis strain FAM 17919]
ATGAAAAAAAATAAAAAAATTAATCCCAAATTAAAATGGGGAATCTCGATTGGTCTAATTGTTGTTGCCCTTTTAGCTTT
ATTTTATCCAACAAGTTACTATGTGGAAATGCCCGGAACAACCGAGCCTTTAGGAAAAATGGTCAAAGTTGAAGGCAAAA
AAGATGAACATAAAGGTGATTTTTTCCTGACGACTGTCCAAATTGCACGAGCAAATCTTGCTACAATGATTTACAGCCAT
TTTAATAGTTTTACAAGCATTTACAGTGAGCAAGAAATGACTGGTGGACTTAACGACGCACAGTTCAACCGTGTCAACCA
GTTTTACATGGAAACGGCACAGAATACAGCGATTTATCAAGCTTTTAAATTAGCTAATAAACCTTATGAACTTAAATATG
AAGGCGTTTATGTCCTTGATATTGCCAAAAATTCGACCTTTAAAAATAAGCTAGAACTTGCAGATACGATTACAGCAGTC
AATGGTCAACAGTTTACATCAAGTGCCGACATGATTGCTTATGTTTCCAAACAAAAAGTCGGTGATTCAGTAACGATTGA
ATACACGAGAATTGACGGCACAAAGCACAAGTCAACTGGCAAATACATCAAAATTGCTAATGGAAAAACAGGAATTGGGA
TCAGCCTAGTTGACCATACTGAAGTCGTGACGACTCCAAAAGTTACTGTCAACGCGGGTTCAATCGGTGGTCCCTCTGCG
GGGATGATGTTTACACTAGAAATTTACAGTCAGTTGACAGGAAAAGATTTGCGAAACGGTCGCGAAATTGCTGGAACTGG
GACGATTGAACATGACGGAAGCATTGGCCAAATCGGCGGTGTTGATAAAAAAGTAGCCACAGCGAGCAAAGAAGGGGCAA
AGGTCTTCTTGGTGCCTGACTCAGGCACCAAAAAAGAAAGTAGCAACAATTACCTTGGAGCCAAAGCCGCCGCTAAAAAA
CTAAAAACGAAGATGAAAATCGTTCCCGTCAAAACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (134-194)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (227-338)

3D structure

• AlphaFold DB: S6FVM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.491