Detailed information NTG0665644

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MPM52_RS09935
• Genome accession: NZ_CP093930
• Coordinates: 1995774..1996817 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain WA121-2010_15611
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1990774..2001817

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MPM52_RS09905 (MPM52_09905)	-	1991195..1992451 (-)	1257	WP_078098242.1	aminopeptidase	-
MPM52_RS09910 (MPM52_09910)	-	1992454..1992654 (-)	201	WP_000180460.1	DUF1128 family protein	-
MPM52_RS09915 (MPM52_09915)	-	1992801..1993265 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MPM52_RS09920 (MPM52_09920)	-	1993272..1993547 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MPM52_RS09925 (MPM52_09925)	-	1993825..1995042 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
MPM52_RS09930 (MPM52_09930)	vraR	1995155..1995784 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MPM52_RS09935 (MPM52_09935)	vraS	1995774..1996817 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MPM52_RS09940 (MPM52_09940)	liaF	1996814..1997515 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MPM52_RS09945 (MPM52_09945)	-	1997530..1997916 (-)	387	WP_001110179.1	hypothetical protein	-
MPM52_RS09950 (MPM52_09950)	map	1998133..1998891 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MPM52_RS09955 (MPM52_09955)	-	1999363..2000349 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
MPM52_RS09960 (MPM52_09960)	-	2000780..2001193 (-)	414	WP_001557448.1	hypothetical protein	-
MPM52_RS09965 (MPM52_09965)	-	2001222..2001332 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=665644 MPM52_RS09935 WP_001017131.1 1995774..1996817(-) (vraS) [Staphylococcus aureus strain WA121-2010_15611]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=665644 MPM52_RS09935 WP_001017131.1 1995774..1996817(-) (vraS) [Staphylococcus aureus strain WA121-2010_15611]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1