Detailed information NTG0665007

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MPF55_RS03305
• Genome accession: NZ_CP093527
• Coordinates: 702985..704028 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 697R
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 697985..709028

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MPF55_RS03275 (MPF55_03275)	-	698411..698521 (+)	111	WP_001790257.1	hypothetical protein	-
MPF55_RS03280 (MPF55_03280)	-	698550..698963 (+)	414	WP_025174552.1	hypothetical protein	-
MPF55_RS03285 (MPF55_03285)	-	699396..700382 (-)	987	WP_000999708.1	aromatic acid exporter family protein	-
MPF55_RS03290 (MPF55_03290)	map	700911..701669 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MPF55_RS03295 (MPF55_03295)	-	701886..702272 (+)	387	WP_240696954.1	hypothetical protein	-
MPF55_RS03300 (MPF55_03300)	liaF	702287..702988 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MPF55_RS03305 (MPF55_03305)	vraS	702985..704028 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MPF55_RS03310 (MPF55_03310)	vraR	704018..704647 (+)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
MPF55_RS03315 (MPF55_03315)	-	704732..705976 (-)	1245	WP_064125696.1	YihY/virulence factor BrkB family protein	-
MPF55_RS03320 (MPF55_03320)	-	706254..706529 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
MPF55_RS03325 (MPF55_03325)	-	706536..707000 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MPF55_RS03330 (MPF55_03330)	-	707147..707347 (+)	201	WP_000180460.1	DUF1128 family protein	-
MPF55_RS03335 (MPF55_03335)	-	707350..708606 (+)	1257	WP_078065149.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=665007 MPF55_RS03305 WP_001017131.1 702985..704028(+) (vraS) [Staphylococcus aureus strain 697R]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=665007 MPF55_RS03305 WP_001017131.1 702985..704028(+) (vraS) [Staphylococcus aureus strain 697R]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1