Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   MMZ11_RS11600 Genome accession   NZ_CP093222
Coordinates   2449901..2451262 (+) Length   453 a.a.
NCBI ID   WP_001631036.1    Uniprot ID   -
Organism   Staphylococcus epidermidis strain CICARIA     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2434089..2469017 2449901..2451262 within 0


Gene organization within MGE regions


Location: 2434089..2469017
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MMZ11_RS11530 (MMZ11_11530) - 2435681..2438089 (-) 2409 WP_002485759.1 heavy metal translocating P-type ATPase -
  MMZ11_RS11535 (MMZ11_11535) - 2438346..2439041 (-) 696 WP_225793074.1 ZIP family metal transporter -
  MMZ11_RS11540 (MMZ11_11540) - 2439367..2439768 (-) 402 WP_002485756.1 metalloregulator ArsR/SmtB family transcription factor -
  MMZ11_RS11545 (MMZ11_11545) lspA 2440003..2440380 (+) 378 WP_011082547.1 signal peptidase II -
  MMZ11_RS11550 (MMZ11_11550) - 2440408..2441082 (-) 675 WP_011082546.1 IS6-like element IS257 family transposase -
  MMZ11_RS11555 (MMZ11_11555) - 2441107..2441331 (-) 225 WP_070866987.1 hypothetical protein -
  MMZ11_RS11560 (MMZ11_11560) - 2441514..2442671 (-) 1158 WP_002485721.1 hypothetical protein -
  MMZ11_RS11565 (MMZ11_11565) - 2442716..2443285 (-) 570 WP_002470562.1 hypothetical protein -
  MMZ11_RS11570 (MMZ11_11570) - 2443406..2444356 (+) 951 Protein_2240 transposase -
  MMZ11_RS11575 (MMZ11_11575) - 2445479..2447404 (-) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -
  MMZ11_RS11580 (MMZ11_11580) - 2447734..2448060 (-) 327 WP_000391495.1 metalloregulator ArsR/SmtB family transcription factor -
  MMZ11_RS11585 (MMZ11_11585) - 2448267..2448626 (+) 360 WP_001631039.1 hypothetical protein -
  MMZ11_RS11590 (MMZ11_11590) - 2448738..2449076 (-) 339 Protein_2244 recombinase family protein -
  MMZ11_RS11595 (MMZ11_11595) - 2449085..2449714 (+) 630 Protein_2245 hypothetical protein -
  MMZ11_RS11600 (MMZ11_11600) ccrA 2449901..2451262 (+) 1362 WP_001631036.1 recombinase family protein Machinery gene
  MMZ11_RS11605 (MMZ11_11605) ccrB 2451259..2452887 (+) 1629 WP_011082541.1 recombinase family protein Machinery gene
  MMZ11_RS11610 (MMZ11_11610) - 2453388..2453738 (+) 351 WP_002485722.1 SAUGI family uracil-DNA glycosylase inhibitor -
  MMZ11_RS11615 (MMZ11_11615) - 2453825..2454136 (+) 312 WP_002501910.1 DUF960 family protein -
  MMZ11_RS11620 (MMZ11_11620) - 2454152..2454418 (+) 267 Protein_2250 DUF1643 domain-containing protein -
  MMZ11_RS11625 (MMZ11_11625) - 2454669..2455868 (+) 1200 WP_071813246.1 IS110-like element ISSep2 family transposase -
  MMZ11_RS11630 (MMZ11_11630) - 2455976..2456215 (+) 240 Protein_2252 DUF1643 domain-containing protein -
  MMZ11_RS11635 (MMZ11_11635) - 2456230..2456450 (+) 221 Protein_2253 hypothetical protein -
  MMZ11_RS11640 (MMZ11_11640) - 2456613..2457023 (+) 411 WP_001631031.1 DUF2871 domain-containing protein -
  MMZ11_RS11645 (MMZ11_11645) - 2457695..2458192 (+) 498 WP_001631030.1 GNAT family N-acetyltransferase -
  MMZ11_RS11650 (MMZ11_11650) - 2458254..2458470 (+) 217 Protein_2256 IS5/IS1182 family transposase -
  MMZ11_RS11655 (MMZ11_11655) - 2458515..2459717 (-) 1203 WP_001631029.1 restriction endonuclease subunit S -
  MMZ11_RS11660 (MMZ11_11660) - 2459710..2459853 (-) 144 WP_001631028.1 restriction endonuclease subunit R -
  MMZ11_RS11665 (MMZ11_11665) - 2460038..2460838 (-) 801 WP_000749912.1 abortive infection family protein -
  MMZ11_RS11670 (MMZ11_11670) - 2460868..2462022 (-) 1155 WP_011082538.1 ATP-binding protein -
  MMZ11_RS11675 (MMZ11_11675) - 2462477..2463523 (+) 1047 WP_001042023.1 hypothetical protein -
  MMZ11_RS11680 (MMZ11_11680) - 2463716..2464012 (+) 297 WP_011082537.1 single-stranded DNA-binding protein -
  MMZ11_RS11685 (MMZ11_11685) - 2464012..2465805 (+) 1794 WP_011082536.1 DUF927 domain-containing protein -
  MMZ11_RS11690 (MMZ11_11690) ccrA 2466039..2467388 (+) 1350 WP_011082535.1 recombinase family protein Machinery gene

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 53316.45 Da        Isoelectric Point: 9.8596

>NTDB_id=662723 MMZ11_RS11600 WP_001631036.1 2449901..2451262(+) (ccrA) [Staphylococcus epidermidis strain CICARIA]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=662723 MMZ11_RS11600 WP_001631036.1 2449901..2451262(+) (ccrA) [Staphylococcus epidermidis strain CICARIA]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(168-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

54.628

97.792

0.534
  ccrA Staphylococcus aureus N315

50.564

97.792

0.494