Detailed information NTG0662699

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MMZ11_RS04265
• Genome accession: NZ_CP093222
• Coordinates: 887753..888799 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain CICARIA
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 882753..893799

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MMZ11_RS04240 (MMZ11_04240)	-	883894..884430 (+)	537	WP_001830372.1	hypothetical protein	-
MMZ11_RS04245 (MMZ11_04245)	-	884581..885567 (-)	987	WP_011082745.1	aromatic acid exporter family protein	-
MMZ11_RS04250 (MMZ11_04250)	map	885741..886496 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
MMZ11_RS04255 (MMZ11_04255)	-	886654..887040 (+)	387	WP_001830382.1	hypothetical protein	-
MMZ11_RS04260 (MMZ11_04260)	liaF	887055..887756 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
MMZ11_RS04265 (MMZ11_04265)	vraS	887753..888799 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MMZ11_RS04270 (MMZ11_04270)	vraR	888789..889418 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MMZ11_RS04275 (MMZ11_04275)	-	889475..890653 (-)	1179	WP_002485151.1	YihY/virulence factor BrkB family protein	-
MMZ11_RS04280 (MMZ11_04280)	-	891060..891344 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MMZ11_RS04285 (MMZ11_04285)	-	891352..891816 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MMZ11_RS04290 (MMZ11_04290)	-	891957..892172 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MMZ11_RS04295 (MMZ11_04295)	-	892174..893415 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=662699 MMZ11_RS04265 WP_001830374.1 887753..888799(+) (vraS) [Staphylococcus epidermidis strain CICARIA]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=662699 MMZ11_RS04265 WP_001830374.1 887753..888799(+) (vraS) [Staphylococcus epidermidis strain CICARIA]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92