Detailed information NTG0662458

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MNU43_RS04715
• Genome accession: NZ_CP093205
• Coordinates: 1019537..1020583 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain TSM-36
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1014537..1025583

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MNU43_RS04690 (MNU43_04685)	-	1015678..1016214 (+)	537	WP_001830372.1	hypothetical protein	-
MNU43_RS04695 (MNU43_04690)	-	1016365..1017351 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
MNU43_RS04700 (MNU43_04695)	map	1017525..1018280 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
MNU43_RS04705 (MNU43_04700)	-	1018438..1018824 (+)	387	WP_001830382.1	hypothetical protein	-
MNU43_RS04710 (MNU43_04705)	liaF	1018839..1019540 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
MNU43_RS04715 (MNU43_04710)	vraS	1019537..1020583 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MNU43_RS04720 (MNU43_04715)	vraR	1020573..1021202 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MNU43_RS04725 (MNU43_04720)	-	1021259..1022437 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
MNU43_RS04730 (MNU43_04725)	-	1022844..1023128 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MNU43_RS04735 (MNU43_04730)	-	1023136..1023600 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MNU43_RS04740 (MNU43_04735)	-	1023741..1023956 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MNU43_RS04745 (MNU43_04740)	-	1023958..1025199 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=662458 MNU43_RS04715 WP_001830374.1 1019537..1020583(+) (vraS) [Staphylococcus epidermidis strain TSM-36]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=662458 MNU43_RS04715 WP_001830374.1 1019537..1020583(+) (vraS) [Staphylococcus epidermidis strain TSM-36]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92