Detailed information NTG0662422

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MNU47_RS04380
• Genome accession: NZ_CP093202
• Coordinates: 942205..943251 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain TSM-31
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 937205..948251

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MNU47_RS04355 (MNU47_04350)	-	938346..938882 (+)	537	WP_001830372.1	hypothetical protein	-
MNU47_RS04360 (MNU47_04355)	-	939033..940019 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
MNU47_RS04365 (MNU47_04360)	map	940193..940948 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
MNU47_RS04370 (MNU47_04365)	-	941106..941492 (+)	387	WP_254107340.1	hypothetical protein	-
MNU47_RS04375 (MNU47_04370)	liaF	941507..942208 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
MNU47_RS04380 (MNU47_04375)	vraS	942205..943251 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MNU47_RS04385 (MNU47_04380)	vraR	943241..943870 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MNU47_RS04390 (MNU47_04385)	-	943927..945105 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
MNU47_RS04395 (MNU47_04390)	-	945512..945796 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MNU47_RS04400 (MNU47_04395)	-	945804..946268 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MNU47_RS04405 (MNU47_04400)	-	946409..946624 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MNU47_RS04410 (MNU47_04405)	-	946626..947867 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=662422 MNU47_RS04380 WP_001830374.1 942205..943251(+) (vraS) [Staphylococcus epidermidis strain TSM-31]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=662422 MNU47_RS04380 WP_001830374.1 942205..943251(+) (vraS) [Staphylococcus epidermidis strain TSM-31]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92