Detailed information NTG0662317

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MNU37_RS04595
• Genome accession: NZ_CP093193
• Coordinates: 978972..980018 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain TMDU-323
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 973972..985018

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MNU37_RS04570 (MNU37_04565)	-	975113..975649 (+)	537	WP_001830372.1	hypothetical protein	-
MNU37_RS04575 (MNU37_04570)	-	975800..976786 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
MNU37_RS04580 (MNU37_04575)	map	976960..977715 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
MNU37_RS04585 (MNU37_04580)	-	977873..978259 (+)	387	WP_001830382.1	hypothetical protein	-
MNU37_RS04590 (MNU37_04585)	liaF	978274..978975 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
MNU37_RS04595 (MNU37_04590)	vraS	978972..980018 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MNU37_RS04600 (MNU37_04595)	vraR	980008..980637 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MNU37_RS04605 (MNU37_04600)	-	980694..981872 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
MNU37_RS04610 (MNU37_04605)	-	982279..982563 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MNU37_RS04615 (MNU37_04610)	-	982571..983035 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MNU37_RS04620 (MNU37_04615)	-	983176..983391 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MNU37_RS04625 (MNU37_04620)	-	983393..984634 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=662317 MNU37_RS04595 WP_001830374.1 978972..980018(+) (vraS) [Staphylococcus epidermidis strain TMDU-323]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=662317 MNU37_RS04595 WP_001830374.1 978972..980018(+) (vraS) [Staphylococcus epidermidis strain TMDU-323]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92