Detailed information NTG0662245

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MNU53_RS04535
• Genome accession: NZ_CP093185
• Coordinates: 976489..977535 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain TMDU-300
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 971489..982535

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MNU53_RS04510 (MNU53_04505)	-	972630..973166 (+)	537	WP_001830372.1	hypothetical protein	-
MNU53_RS04515 (MNU53_04510)	-	973317..974303 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
MNU53_RS04520 (MNU53_04515)	map	974477..975232 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
MNU53_RS04525 (MNU53_04520)	-	975390..975776 (+)	387	WP_001830382.1	hypothetical protein	-
MNU53_RS04530 (MNU53_04525)	liaF	975791..976492 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
MNU53_RS04535 (MNU53_04530)	vraS	976489..977535 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MNU53_RS04540 (MNU53_04535)	vraR	977525..978154 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MNU53_RS04545 (MNU53_04540)	-	978211..979389 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
MNU53_RS04550 (MNU53_04545)	-	979796..980080 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MNU53_RS04555 (MNU53_04550)	-	980088..980552 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MNU53_RS04560 (MNU53_04555)	-	980693..980908 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MNU53_RS04565 (MNU53_04560)	-	980910..982151 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=662245 MNU53_RS04535 WP_001830374.1 976489..977535(+) (vraS) [Staphylococcus epidermidis strain TMDU-300]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=662245 MNU53_RS04535 WP_001830374.1 976489..977535(+) (vraS) [Staphylococcus epidermidis strain TMDU-300]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92