Detailed information NTG0662224

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MNU40_RS08050
• Genome accession: NZ_CP093181
• Coordinates: 1642529..1643575 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain TMDU-265
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1637529..1648575

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MNU40_RS08020 (MNU40_08025)	-	1637913..1639154 (-)	1242	WP_001832467.1	aminopeptidase	-
MNU40_RS08025 (MNU40_08030)	-	1639156..1639371 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MNU40_RS08030 (MNU40_08035)	-	1639512..1639976 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MNU40_RS08035 (MNU40_08040)	-	1639984..1640268 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
MNU40_RS08040 (MNU40_08045)	-	1640675..1641853 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
MNU40_RS08045 (MNU40_08050)	vraR	1641910..1642539 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MNU40_RS08050 (MNU40_08055)	vraS	1642529..1643575 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MNU40_RS08055 (MNU40_08060)	liaF	1643572..1644273 (-)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
MNU40_RS08060 (MNU40_08065)	-	1644288..1644674 (-)	387	WP_001830382.1	hypothetical protein	-
MNU40_RS08065 (MNU40_08070)	map	1644832..1645587 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
MNU40_RS08070 (MNU40_08075)	-	1645761..1646747 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
MNU40_RS08075 (MNU40_08080)	-	1646898..1647434 (-)	537	WP_002470337.1	hypothetical protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=662224 MNU40_RS08050 WP_001830374.1 1642529..1643575(-) (vraS) [Staphylococcus epidermidis strain TMDU-265]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=662224 MNU40_RS08050 WP_001830374.1 1642529..1643575(-) (vraS) [Staphylococcus epidermidis strain TMDU-265]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92