Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | MNU40_RS00305 | Genome accession | NZ_CP093181 |
| Coordinates | 65204..66832 (-) | Length | 542 a.a. |
| NCBI ID | WP_001186596.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain TMDU-265 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 42843..108717 | 65204..66832 | within | 0 |
Gene organization within MGE regions
Location: 42843..108717
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNU40_RS00185 (MNU40_00185) | mecA | 42843..44852 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| MNU40_RS00190 (MNU40_00190) | mecR1 | 44949..46706 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| MNU40_RS00195 (MNU40_00195) | mecI | 46706..47077 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| MNU40_RS00200 (MNU40_00200) | psm-mec | 47162..47230 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| MNU40_RS00205 (MNU40_00205) | - | 47564..48694 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| MNU40_RS00210 (MNU40_00210) | cstB | 48808..50142 (-) | 1335 | Protein_39 | persulfide dioxygenase-sulfurtransferase CstB | - |
| MNU40_RS00215 (MNU40_00215) | - | 50175..51239 (-) | 1065 | WP_254106909.1 | DsrE/DsrF/DrsH-like family protein | - |
| MNU40_RS00220 (MNU40_00220) | cstR | 51375..51635 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| MNU40_RS00225 (MNU40_00225) | - | 51635..52273 (+) | 639 | Protein_42 | sulfite exporter TauE/SafE family protein | - |
| MNU40_RS00230 (MNU40_00235) | - | 52547..53163 (-) | 617 | Protein_43 | CadD family cadmium resistance transporter | - |
| MNU40_RS00235 (MNU40_00240) | - | 53244..55658 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| MNU40_RS00240 (MNU40_00245) | - | 55651..56016 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| MNU40_RS00245 (MNU40_00250) | - | 56254..56631 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| MNU40_RS00250 (MNU40_00255) | - | 56638..58530 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| MNU40_RS00255 (MNU40_00260) | - | 58775..59590 (-) | 816 | WP_000164963.1 | AAA family ATPase | - |
| MNU40_RS00260 (MNU40_00265) | - | 59583..61025 (-) | 1443 | WP_002451367.1 | Mu transposase C-terminal domain-containing protein | - |
| MNU40_RS00265 (MNU40_00270) | - | 60997..61590 (-) | 594 | WP_000690638.1 | recombinase family protein | - |
| MNU40_RS00270 (MNU40_00275) | - | 61878..62297 (+) | 420 | WP_000616116.1 | fosfomycin resistance bacillithiol transferase FosD | - |
| MNU40_RS00275 (MNU40_00280) | - | 62309..62755 (+) | 447 | WP_000199401.1 | GNAT family N-acetyltransferase | - |
| MNU40_RS00280 (MNU40_00285) | - | 62923..63246 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| MNU40_RS00285 (MNU40_00290) | - | 63239..63445 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| MNU40_RS00290 (MNU40_00295) | - | 63447..63968 (-) | 522 | WP_254106910.1 | DUF1643 domain-containing protein | - |
| MNU40_RS00295 (MNU40_00300) | - | 63987..64298 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| MNU40_RS00300 (MNU40_00305) | - | 64383..64733 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| MNU40_RS00305 (MNU40_00310) | ccrB | 65204..66832 (-) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| MNU40_RS00310 (MNU40_00315) | ccrA | 66853..68199 (-) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| MNU40_RS00315 (MNU40_00320) | - | 68392..68667 (-) | 276 | WP_001791132.1 | hypothetical protein | - |
| MNU40_RS00320 (MNU40_00325) | - | 68757..70544 (-) | 1788 | WP_000181743.1 | DUF927 domain-containing protein | - |
| MNU40_RS00325 (MNU40_00330) | - | 70544..70828 (-) | 285 | WP_000659554.1 | DUF1413 domain-containing protein | - |
| MNU40_RS00330 (MNU40_00335) | - | 70966..72015 (+) | 1050 | WP_000613217.1 | hypothetical protein | - |
| MNU40_RS00335 (MNU40_00340) | - | 72068..72640 (+) | 573 | WP_000489177.1 | ADP-ribosyltransferase | - |
| MNU40_RS00340 (MNU40_00345) | - | 72972..73298 (+) | 327 | WP_000624048.1 | helix-turn-helix domain-containing protein | - |
| MNU40_RS00345 (MNU40_00350) | - | 73335..74168 (+) | 834 | WP_000694291.1 | CPBP family intramembrane glutamic endopeptidase | - |
| MNU40_RS00350 (MNU40_00355) | - | 74373..74537 (+) | 165 | WP_001028954.1 | hypothetical protein | - |
| MNU40_RS00355 (MNU40_00360) | - | 74854..75627 (+) | 774 | WP_000998885.1 | hypothetical protein | - |
| MNU40_RS00360 (MNU40_00365) | - | 75865..76224 (-) | 360 | WP_000432280.1 | DUF4870 domain-containing protein | - |
| MNU40_RS00365 (MNU40_00370) | - | 76389..77459 (-) | 1071 | WP_001054882.1 | nitronate monooxygenase family protein | - |
| MNU40_RS00370 (MNU40_00375) | - | 77472..78338 (-) | 867 | WP_001052247.1 | LysR family transcriptional regulator | - |
| MNU40_RS00375 (MNU40_00380) | - | 78325..79515 (-) | 1191 | WP_000716034.1 | YbfB/YjiJ family MFS transporter | - |
| MNU40_RS00380 (MNU40_00385) | - | 79726..80400 (+) | 675 | Protein_73 | IS6 family transposase | - |
| MNU40_RS00385 (MNU40_00390) | - | 80460..80888 (-) | 429 | WP_000671997.1 | VOC family protein | - |
| MNU40_RS00390 (MNU40_00395) | - | 80969..81898 (+) | 930 | WP_002504713.1 | HTH domain-containing protein | - |
| MNU40_RS00395 (MNU40_00400) | - | 82060..84072 (+) | 2013 | WP_012088687.1 | hypothetical protein | - |
| MNU40_RS00400 (MNU40_00405) | - | 84242..85351 (+) | 1110 | WP_254104810.1 | DNA polymerase | - |
| MNU40_RS00405 (MNU40_00410) | - | 85344..85715 (+) | 372 | WP_002437511.1 | hypothetical protein | - |
| MNU40_RS00410 (MNU40_00415) | - | 85712..87355 (+) | 1644 | WP_002504708.1 | DUF5906 domain-containing protein | - |
| MNU40_RS00415 (MNU40_00420) | - | 87580..89256 (+) | 1677 | WP_002504707.1 | recombinase family protein | - |
| MNU40_RS00420 (MNU40_00425) | - | 89362..89700 (+) | 339 | WP_000171557.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| MNU40_RS00425 (MNU40_00430) | - | 89796..90107 (+) | 312 | WP_001083108.1 | DUF960 family protein | - |
| MNU40_RS00430 (MNU40_00435) | - | 90123..90629 (+) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| MNU40_RS00435 (MNU40_00440) | - | 90650..90967 (+) | 318 | WP_060934404.1 | JAB domain-containing protein | - |
| MNU40_RS00440 (MNU40_00445) | - | 91086..92171 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| MNU40_RS00445 (MNU40_00450) | - | 92168..94060 (+) | 1893 | WP_254104727.1 | site-specific integrase | - |
| MNU40_RS00450 (MNU40_00455) | - | 94067..94444 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| MNU40_RS00455 (MNU40_00460) | - | 94595..95377 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| MNU40_RS00460 (MNU40_00465) | erm(A) | 95503..96234 (-) | 732 | WP_254104725.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| MNU40_RS13490 | - | 96317..96376 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| MNU40_RS00465 (MNU40_00470) | - | 96768..97430 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| MNU40_RS13455 | - | 97659..97808 (+) | 150 | Protein_92 | JAB domain-containing protein | - |
| MNU40_RS00475 (MNU40_00480) | - | 97978..98850 (+) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| MNU40_RS00480 (MNU40_00485) | - | 98907..99197 (+) | 291 | WP_000065261.1 | hypothetical protein | - |
| MNU40_RS00485 (MNU40_00490) | - | 99213..99701 (+) | 489 | WP_000393586.1 | hypothetical protein | - |
| MNU40_RS00490 (MNU40_00495) | - | 99836..100363 (+) | 528 | WP_002504704.1 | hypothetical protein | - |
| MNU40_RS00495 (MNU40_00500) | - | 100425..100868 (+) | 444 | WP_000941333.1 | hypothetical protein | - |
| MNU40_RS00500 (MNU40_00505) | - | 100817..101038 (+) | 222 | WP_002504703.1 | hypothetical protein | - |
| MNU40_RS00505 (MNU40_00510) | - | 101432..101755 (+) | 324 | WP_001176049.1 | PepSY domain-containing protein | - |
| MNU40_RS00510 (MNU40_00515) | - | 101833..104952 (-) | 3120 | WP_002504702.1 | type I restriction endonuclease subunit R | - |
| MNU40_RS00515 (MNU40_00520) | - | 104936..106210 (-) | 1275 | WP_002504701.1 | restriction endonuclease subunit S | - |
| MNU40_RS00520 (MNU40_00525) | - | 106200..107714 (-) | 1515 | WP_002504700.1 | class I SAM-dependent DNA methyltransferase | - |
| MNU40_RS00525 (MNU40_00530) | - | 107905..108717 (+) | 813 | WP_002504699.1 | abortive infection system antitoxin AbiGi family protein | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62274.15 Da Isoelectric Point: 9.7334
>NTDB_id=662198 MNU40_RS00305 WP_001186596.1 65204..66832(-) (ccrB) [Staphylococcus epidermidis strain TMDU-265]
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
Nucleotide
Download Length: 1629 bp
>NTDB_id=662198 MNU40_RS00305 WP_001186596.1 65204..66832(-) (ccrB) [Staphylococcus epidermidis strain TMDU-265]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
86.531 |
100 |
0.865 |