Detailed information NTG0662065

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MNU56_RS04365
• Genome accession: NZ_CP093165
• Coordinates: 936197..937243 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain TMDU-41
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 931197..942243

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MNU56_RS04340 (MNU56_04335)	-	932338..932874 (+)	537	WP_001830372.1	hypothetical protein	-
MNU56_RS04345 (MNU56_04340)	-	933025..934011 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
MNU56_RS04350 (MNU56_04345)	map	934185..934940 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
MNU56_RS04355 (MNU56_04350)	-	935098..935484 (+)	387	WP_001830382.1	hypothetical protein	-
MNU56_RS04360 (MNU56_04355)	liaF	935499..936200 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
MNU56_RS04365 (MNU56_04360)	vraS	936197..937243 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MNU56_RS04370 (MNU56_04365)	vraR	937233..937862 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MNU56_RS04375 (MNU56_04370)	-	937919..939097 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
MNU56_RS04380 (MNU56_04375)	-	939504..939788 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MNU56_RS04385 (MNU56_04380)	-	939796..940260 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MNU56_RS04390 (MNU56_04385)	-	940401..940616 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MNU56_RS04395 (MNU56_04390)	-	940618..941859 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=662065 MNU56_RS04365 WP_001830374.1 936197..937243(+) (vraS) [Staphylococcus epidermidis strain TMDU-41]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=662065 MNU56_RS04365 WP_001830374.1 936197..937243(+) (vraS) [Staphylococcus epidermidis strain TMDU-41]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92