Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   ML603_RS06695 Genome accession   NZ_CP092887
Coordinates   1346814..1349105 (+) Length   763 a.a.
NCBI ID   WP_115246233.1    Uniprot ID   A0A380JW02
Organism   Streptococcus dysgalactiae subsp. equisimilis strain Karl     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 1341814..1354105
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ML603_RS06670 (ML603_06670) feoB 1341904..1344063 (-) 2160 WP_241066917.1 ferrous iron transport protein B -
  ML603_RS06675 (ML603_06675) - 1344060..1344539 (-) 480 WP_111717082.1 ferrous iron transport protein A -
  ML603_RS06680 (ML603_06680) - 1344737..1345471 (-) 735 WP_138126075.1 amino acid ABC transporter ATP-binding protein -
  ML603_RS06685 (ML603_06685) - 1345471..1346157 (-) 687 WP_241066918.1 amino acid ABC transporter permease -
  ML603_RS06690 (ML603_06690) - 1346285..1346515 (-) 231 WP_003051836.1 DUF1797 family protein -
  ML603_RS06695 (ML603_06695) clpE 1346814..1349105 (+) 2292 WP_115246233.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  ML603_RS06700 (ML603_06700) - 1349223..1349678 (+) 456 WP_111717090.1 NUDIX hydrolase -
  ML603_RS06705 (ML603_06705) - 1349728..1350030 (+) 303 WP_003051842.1 DUF1827 family protein -
  ML603_RS06710 (ML603_06710) ileS 1350445..1353246 (-) 2802 WP_241066920.1 isoleucine--tRNA ligase -

Sequence

Protein


Download         Length: 763 a.a.        Molecular weight: 84911.17 Da        Isoelectric Point: 5.2743

>NTDB_id=660937 ML603_RS06695 WP_115246233.1 1346814..1349105(+) (clpE) [Streptococcus dysgalactiae subsp. equisimilis strain Karl]
MLCQNCNLNESTIHLYTNVNGKQKQVDLCQNCYQIMKTDPTNPILGGLNGGQRAQERSSNPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRHGGHFNGQRPTQPQTPNQQAKGLLEEFGINVTDIARHGDIDPVIGRDDEITRVIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIVDGTVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
IAKYKEMQAQKVDEQDIPIITEKTIEAIIEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSADNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKDNLLHIVDLMLEDVNKRLGYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKDLRAIMTSNGNIMIKAAKKDETVTAKQDQTDEN

Nucleotide


Download         Length: 2292 bp        

>NTDB_id=660937 ML603_RS06695 WP_115246233.1 1346814..1349105(+) (clpE) [Streptococcus dysgalactiae subsp. equisimilis strain Karl]
ATGCTTTGTCAAAATTGTAATTTAAACGAATCAACCATTCACCTCTACACGAATGTTAATGGAAAACAAAAACAAGTTGA
CCTTTGTCAAAACTGTTATCAAATCATGAAGACCGACCCTACTAATCCTATTTTAGGTGGTCTAAATGGAGGACAAAGAG
CCCAAGAACGCTCATCCAACCCCTTCTTTGATGACTTTTTTGGTGATTTAAATAATTTTAGAGCCTTTGGCAACCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGTGGGGGACGCCATGGTGGTCATTTCAATGGGCAACGTCCCAC
TCAACCACAAACACCAAATCAGCAAGCAAAAGGCCTGCTAGAAGAATTTGGCATTAATGTCACAGATATTGCAAGACATG
GTGATATCGACCCTGTCATCGGTCGAGATGACGAGATTACACGTGTCATCGAAATCCTTAACCGTCGGACTAAAAATAAC
CCTGTGCTTATTGGGGAACCAGGAGTTGGTAAAACAGCTGTTGTAGAAGGTCTAGCCCAGAAAATTGTAGATGGCACAGT
ACCTCACAAATTGCAAGGTAAGCAAGTGATTCGTCTAGATGTGGTTAGTCTTGTTCAAGGCACAGGTATCCGTGGTCAAT
TCGAAGAACGCATGCAAAAATTAATGGAAGAAATTCGTCAGCGCAAAGATGTGATTCTCTTTATTGATGAAATTCATGAA
ATTGTAGGTGCTGGTTCTGCTGGAGATGGCAATATGGATGCTGGCAATATTTTAAAACCAGCCTTGGCCCGTGGTGAGTT
GCAACTCGTTGGTGCTACTACCTTAAATGAATACCGTATTATTGAAAAAGATGCTGCCTTGGAGCGGCGGATGCAGCCGG
TGAAAGTTGACGAACCTTCTGTAGAAGAAACCATTACCATCTTAAAAGGTATCCAGCCCAAATACGAAGACTATCATCAT
GTCAAATATAGCCCAGCAGCTATCGAGGCTGCTGCACACTTATCCAATCGCTACATCCAAGACCGATTCCTCCCTGATAA
GGCCATTGACCTTCTGGACGAAGCTGGTTCAAAAATGAATTTAACCCTTAATTTTGTTGACCCTAAAGAGATTGACAAAC
GTCTGATTGAAGCAGAAAACCTCAAGGCTCAAGCAACTCGTGACGAAGATTACGAACGAGCAGCCTATTTCCGTGATCAA
ATTGCGAAATACAAGGAAATGCAAGCTCAAAAAGTCGACGAACAGGATATTCCTATAATTACTGAAAAAACCATTGAAGC
CATCATTGAACAAAAAACCAATATTCCAGTTGGCGACTTGAAAGAAAAAGAACAATCTCAACTCGTTAATTTGGCTAATG
ATTTGAAAGCTCACGTGATTGGCCAAGATGATGCCGTTGACAAAATTGCCAAGGCCATCCGCCGGAACCGTGTGGGATTG
GGAACTCCAAATCGTCCTATTGGTTCTTTCCTATTCGTTGGGCCAACAGGTGTTGGTAAAACAGAGTTATCTAAGCAACT
AGCTATTGAACTCTTTGGCTCTGCTGACAATATGATTCGCTTTGATATGTCCGAATACATGGAAAAACATGCCGTTGCTA
AATTAGTCGGGGCTCCTCCTGGTTATGTGGGCTATGAAGAAGCTGGCCAGTTGACGGAACAAGTTCGCCGCAACCCATAT
TCACTTATTCTCTTAGATGAAGTGGAAAAGGCTCATCCTGACGTCATGCACATGTTTTTACAAGTTCTTGATGATGGCCG
TTTAACAGATGGTCAAGGACGGACAGTCAGCTTCAAAGATACTATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTTGGATTTGGTGCAGCTAGAGAAGGACGAACAAGCTCTGTCCTTGGTGAATTAAGTAACTTCTTCAGC
CCAGAGTTCATGAACCGTTTCGATGGTATTATTGAATTTAAGGCCTTGAGCAAAGATAACCTCTTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATAAGCGCTTAGGCTATAATGGGATTCACCTTGATGTGACACAAAAAGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGTGCTCGACCACTCCGTCGCACCATCCAAGATTATATCGAAGATGCGATTACG
GACTACTATTTGGAACACCCCACTGAAAAGGACTTGCGTGCTATAATGACAAGTAACGGTAATATCATGATTAAAGCTGC
CAAAAAAGATGAAACGGTAACAGCTAAACAAGATCAGACCGACGAGAACTAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(656-730)

AAA lid domain (AAA_lid_9)

(300-397)

ATPase family associated with various cellular activities (AAA) (AAA)

(162-281)

AAA domain (Cdc48 subfamily) (AAA_2)

(485-648)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A380JW02

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

85.714

99.083

0.849
  clpE Streptococcus pneumoniae Rx1

83.926

99.476

0.835
  clpE Streptococcus pneumoniae D39

83.926

99.476

0.835
  clpE Streptococcus pneumoniae R6

83.926

99.476

0.835
  clpE Streptococcus pneumoniae TIGR4

83.794

99.476

0.834
  clpC Lactococcus lactis subsp. cremoris KW2

76.63

96.461

0.739
  clpC Bacillus subtilis subsp. subtilis str. 168

49.781

89.777

0.447
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.462

85.19

0.396
  clpC Streptococcus pneumoniae Rx1

48

81.913

0.393
  clpC Streptococcus pneumoniae D39

48

81.913

0.393
  clpC Streptococcus pneumoniae TIGR4

48

81.913

0.393
  clpC Streptococcus mutans UA159

47.573

80.996

0.385
  clpC Streptococcus thermophilus LMD-9

46.635

81.782

0.381
  clpC Streptococcus thermophilus LMG 18311

46.314

81.782

0.379