Detailed information    

insolico Bioinformatically predicted

Overview

Name   braR   Type   Regulator
Locus tag   MKI64_RS13220 Genome accession   NZ_CP092556
Coordinates   2645490..2646164 (-) Length   224 a.a.
NCBI ID   WP_000866106.1    Uniprot ID   -
Organism   Staphylococcus aureus strain VMRSA-WC062     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2637967..2705679 2645490..2646164 within 0
IScluster/Tn 2638770..2654400 2645490..2646164 within 0


Gene organization within MGE regions


Location: 2637967..2705679
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MKI64_RS13160 (MKI64_002607) - 2637967..2638263 (-) 297 WP_000447709.1 DUF4176 domain-containing protein -
  MKI64_RS13165 (MKI64_002608) - 2638251..2638619 (-) 369 WP_000066369.1 hypothetical protein -
  MKI64_RS13170 (MKI64_002609) - 2638634..2638711 (-) 78 Protein_2558 TIGR04197 family type VII secretion effector -
  MKI64_RS13175 (MKI64_002610) - 2638770..2639444 (+) 675 WP_001105987.1 IS6-like element IS257 family transposase -
  MKI64_RS13180 (MKI64_002611) aph(3')-IIIa 2639726..2640520 (-) 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
  MKI64_RS13185 (MKI64_002612) sat4 2640613..2641143 (-) 531 WP_000627289.1 streptothricin N-acetyltransferase Sat4 -
  MKI64_RS13190 (MKI64_002613) - 2641140..2641775 (-) 636 Protein_2562 aminoglycoside 6-adenylyltransferase -
  MKI64_RS13195 (MKI64_002614) - 2641916..2642590 (-) 675 WP_001105960.1 IS6 family transposase -
  MKI64_RS13200 (MKI64_002615) - 2642647..2642823 (-) 177 Protein_2564 undecaprenyl-diphosphate phosphatase -
  MKI64_RS13205 (MKI64_002616) - 2642837..2643574 (-) 738 WP_000369394.1 ABC transporter permease -
  MKI64_RS13210 (MKI64_002617) - 2643567..2644496 (-) 930 WP_000793446.1 ABC transporter ATP-binding protein -
  MKI64_RS13215 (MKI64_002618) - 2644612..2645493 (-) 882 Protein_2567 sensor histidine kinase -
  MKI64_RS13220 (MKI64_002619) braR 2645490..2646164 (-) 675 WP_000866106.1 response regulator transcription factor Regulator
  MKI64_RS13225 (MKI64_002620) - 2646304..2646978 (-) 675 WP_001105960.1 IS6 family transposase -
  MKI64_RS13230 (MKI64_002621) - 2647170..2648582 (-) 1413 WP_000526300.1 PLP-dependent aminotransferase family protein -
  MKI64_RS13235 (MKI64_002622) - 2648681..2649652 (+) 972 WP_000053810.1 fatty acid desaturase family protein -
  MKI64_RS13240 (MKI64_002623) - 2649657..2650277 (+) 621 WP_000941203.1 LysE family transporter -
  MKI64_RS13245 (MKI64_002624) - 2650321..2650494 (+) 174 WP_000044738.1 hypothetical protein -
  MKI64_RS13250 (MKI64_002625) - 2650788..2651462 (-) 675 WP_001105960.1 IS6 family transposase -
  MKI64_RS13255 (MKI64_002626) msr(A) 2651936..2653402 (+) 1467 WP_000438874.1 ABC-F type ribosomal protection protein Msr(A) -
  MKI64_RS13260 (MKI64_002627) - 2653501..2654400 (+) 900 WP_000196698.1 Mph(C) family macrolide 2'-phosphotransferase -
  MKI64_RS13265 (MKI64_002628) - 2654885..2655493 (+) 609 WP_000635274.1 recombinase family protein -
  MKI64_RS13270 (MKI64_002629) cadC 2655765..2656133 (+) 369 WP_000726008.1 Cd(II)/Pb(II)/Zn(II)-sensing metalloregulatory transcriptional repressor CadC -
  MKI64_RS13275 (MKI64_002630) cadA 2656126..2658309 (+) 2184 WP_000003266.1 cadmium-translocating P-type ATPase CadA -
  MKI64_RS13280 (MKI64_002631) - 2658449..2658799 (-) 351 Protein_2580 IS6-like element IS257 family transposase -
  MKI64_RS13285 (MKI64_002632) - 2658869..2659556 (-) 688 Protein_2581 DUF536 domain-containing protein -
  MKI64_RS13290 (MKI64_002633) - 2660049..2660480 (+) 432 Protein_2582 replication initiator protein A -
  MKI64_RS13295 (MKI64_002634) - 2660539..2661213 (-) 675 WP_001105987.1 IS6-like element IS257 family transposase -
  MKI64_RS13300 (MKI64_002635) - 2661245..2661694 (+) 450 WP_078071306.1 ParA family protein -
  MKI64_RS13305 (MKI64_002636) - 2661697..2661975 (+) 279 WP_000774717.1 hypothetical protein -
  MKI64_RS13310 (MKI64_002637) - 2662103..2662738 (+) 636 Protein_2586 aminoglycoside 6-adenylyltransferase -
  MKI64_RS13315 (MKI64_002638) sat4 2662735..2663266 (+) 532 Protein_2587 streptothricin N-acetyltransferase Sat4 -
  MKI64_RS13320 (MKI64_002639) - 2663431..2664153 (+) 723 WP_242417831.1 APH(3') family aminoglycoside O-phosphotransferase -
  MKI64_RS13325 (MKI64_002640) - 2664429..2664971 (+) 543 WP_002321977.1 HTH domain-containing protein -
  MKI64_RS13330 (MKI64_002641) - 2665001..2665681 (-) 681 WP_001015311.1 IS6-like element IS1216 family transposase -
  MKI64_RS13335 (MKI64_002642) - 2665756..2665851 (-) 96 Protein_2591 recombinase family protein -
  MKI64_RS13340 (MKI64_002643) - 2665976..2668963 (+) 2988 WP_000343406.1 Tn3 family transposase -
  MKI64_RS13345 (MKI64_002644) - 2669112..2669321 (+) 210 Protein_2593 DNA topoisomerase -
  MKI64_RS13350 (MKI64_002645) - 2669456..2669632 (+) 177 Protein_2594 IS6 family transposase -
  MKI64_RS13355 (MKI64_002646) - 2669614..2669970 (+) 357 WP_029756604.1 helix-turn-helix domain-containing protein -
  MKI64_RS13360 (MKI64_002647) - 2670484..2670651 (-) 168 WP_005228365.1 cysteine-rich KTR domain-containing protein -
  MKI64_RS13365 (MKI64_002648) tet(S) 2670739..2672679 (-) 1941 WP_002405437.1 tetracycline resistance ribosomal protection protein Tet(S) -
  MKI64_RS13370 (MKI64_002650) - 2673318..2673998 (+) 681 WP_001015311.1 IS6-like element IS1216 family transposase -
  MKI64_RS13375 (MKI64_002651) - 2674032..2675279 (-) 1248 WP_000913852.1 hypothetical protein -
  MKI64_RS13380 (MKI64_002652) - 2675333..2675707 (-) 375 WP_000713874.1 lactococcin 972 family bacteriocin -
  MKI64_RS13385 (MKI64_002653) - 2675840..2676301 (+) 462 WP_000389746.1 helix-turn-helix domain-containing protein -
  MKI64_RS13390 (MKI64_002654) - 2676817..2677233 (-) 417 WP_001232860.1 hypothetical protein -
  MKI64_RS13395 (MKI64_002655) - 2677235..2677516 (-) 282 WP_000353845.1 hypothetical protein -
  MKI64_RS13400 (MKI64_002656) - 2677663..2678343 (+) 681 WP_001015311.1 IS6-like element IS1216 family transposase -
  MKI64_RS13405 (MKI64_002657) - 2678541..2679146 (+) 606 WP_000599739.1 Fic family protein -
  MKI64_RS13410 (MKI64_002658) - 2679162..2679734 (+) 573 WP_000170424.1 recombinase family protein -
  MKI64_RS13415 (MKI64_002659) - 2680207..2680779 (-) 573 WP_073120187.1 IS3 family transposase -
  MKI64_RS13425 (MKI64_002662) - 2682448..2682702 (-) 255 WP_000199136.1 transposase -
  MKI64_RS13430 (MKI64_002663) prgO 2682895..2683170 (-) 276 WP_001196543.1 DNA segregation protein PrgO -
  MKI64_RS13435 (MKI64_002664) - 2683142..2684095 (-) 954 WP_000429439.1 ParA family protein -
  MKI64_RS13440 (MKI64_002665) - 2684707..2686188 (+) 1482 WP_242414046.1 primase C-terminal domain-containing protein -
  MKI64_RS13445 (MKI64_002666) - 2686323..2686619 (+) 297 WP_000053907.1 replication control protein PrgN -
  MKI64_RS13450 (MKI64_002667) - 2686643..2687602 (-) 960 WP_000222573.1 IS30 family transposase -
  MKI64_RS13455 (MKI64_002668) - 2687785..2688411 (+) 627 WP_000833826.1 hypothetical protein -
  MKI64_RS13460 (MKI64_002669) - 2688465..2689145 (+) 681 WP_001015311.1 IS6-like element IS1216 family transposase -
  MKI64_RS13465 (MKI64_002670) - 2689295..2690467 (+) 1173 WP_000195429.1 IS256-like element IS256 family transposase -
  MKI64_RS13470 (MKI64_002671) aph(2'')-Ia 2690597..2692036 (-) 1440 WP_001028144.1 aminoglycoside O-phosphotransferase APH(2'')-Ia -
  MKI64_RS13475 (MKI64_002672) - 2692037..2692428 (-) 392 Protein_2619 GNAT family N-acetyltransferase -
  MKI64_RS13480 (MKI64_002673) - 2692485..2693534 (-) 1050 Protein_2620 IS256-like element IS256 family transposase -
  MKI64_RS13485 (MKI64_002674) - 2693601..2694281 (+) 681 WP_001015311.1 IS6-like element IS1216 family transposase -
  MKI64_RS13490 (MKI64_002675) - 2694335..2694517 (+) 183 Protein_2622 IS6 family transposase -
  MKI64_RS13495 (MKI64_002676) - 2694727..2695323 (+) 597 WP_002296898.1 replication initiation factor domain-containing protein -
  MKI64_RS13500 (MKI64_002678) - 2696286..2696579 (+) 294 WP_001262780.1 hypothetical protein -
  MKI64_RS13505 (MKI64_002679) - 2696613..2697293 (-) 681 WP_001015311.1 IS6-like element IS1216 family transposase -
  MKI64_RS13510 (MKI64_002680) - 2697424..2697876 (+) 453 WP_000751236.1 hypothetical protein -
  MKI64_RS13515 (MKI64_002681) - 2697890..2698579 (+) 690 WP_000718009.1 hypothetical protein -
  MKI64_RS13520 (MKI64_002682) - 2698704..2701055 (+) 2352 WP_000344083.1 glycoside hydrolase domain-containing protein -
  MKI64_RS13525 (MKI64_002683) - 2701144..2701530 (+) 387 WP_000391061.1 hypothetical protein -
  MKI64_RS13530 (MKI64_002684) - 2701855..2702472 (+) 618 WP_001224538.1 recombinase family protein -
  MKI64_RS13535 (MKI64_002685) - 2702513..2702812 (+) 300 WP_000366408.1 BRCT domain-containing protein -
  MKI64_RS13540 (MKI64_002686) - 2703058..2703555 (-) 498 WP_001186972.1 recombinase family protein -
  MKI64_RS13545 (MKI64_002687) - 2703597..2704277 (-) 681 WP_001015311.1 IS6-like element IS1216 family transposase -
  MKI64_RS13550 (MKI64_002688) - 2704294..2704770 (+) 477 WP_029756586.1 recombinase family protein -
  MKI64_RS13555 (MKI64_002689) vanR-A 2704984..2705679 (+) 696 WP_001280781.1 vancomycin resistance response regulator transcription factor VanR-A -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25839.93 Da        Isoelectric Point: 4.9884

>NTDB_id=658792 MKI64_RS13220 WP_000866106.1 2645490..2646164(-) (braR) [Staphylococcus aureus strain VMRSA-WC062]
MKVLIVEDDLVIGKMLAEELKKWQLEPILIEGFNHVMDAFNTNAPELVLLDINLPAFNGYHWCQEIRKVSTVPIIFISSR
NDSMDQVMAMQMGADDFIEKPFNMTVTITKIQALLRRTYDFTTQVNNLTVDDCELLLDAAKLKFNEETIDLTHTELQIMH
SLFQNKGKFVSRNALIEKCWESEHFIDDNTLAVNITRLRKKLQKLGLTDFIETKKNVGYRVGDV

Nucleotide


Download         Length: 675 bp        

>NTDB_id=658792 MKI64_RS13220 WP_000866106.1 2645490..2646164(-) (braR) [Staphylococcus aureus strain VMRSA-WC062]
ATGAAAGTATTAATCGTAGAGGATGACTTAGTTATCGGGAAGATGCTTGCTGAAGAGCTCAAGAAGTGGCAGCTAGAACC
GATCTTAATAGAAGGTTTCAATCATGTAATGGATGCCTTCAACACGAATGCACCGGAACTTGTGTTACTCGATATTAATT
TACCTGCCTTCAATGGTTATCACTGGTGTCAGGAGATTCGTAAAGTTTCTACTGTACCGATTATATTTATTAGTTCGCGT
AACGACAGTATGGATCAAGTAATGGCGATGCAGATGGGTGCGGATGATTTCATTGAGAAGCCATTTAATATGACTGTTAC
AATTACTAAGATTCAAGCACTATTACGCCGCACGTATGATTTCACCACTCAAGTTAATAATTTAACAGTAGATGATTGCG
AGTTACTACTTGATGCAGCAAAGCTTAAATTTAATGAAGAAACCATAGACCTGACACACACTGAATTGCAAATCATGCAT
AGCTTATTCCAGAACAAGGGCAAATTCGTCAGTCGTAATGCGTTAATCGAAAAATGCTGGGAATCAGAACACTTCATTGA
TGACAATACGCTTGCTGTCAACATTACACGTTTACGCAAAAAGCTACAAAAACTAGGACTTACAGATTTTATCGAAACGA
AGAAAAATGTCGGATATCGTGTAGGTGACGTATGA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-220)

Response regulator receiver domain (Response_reg)

(3-111)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  braR Staphylococcus aureus N315

66.516

98.661

0.656