Detailed information
Bioinformatically predicted
Overview
| Name | braR | Type | Regulator |
| Locus tag | MKI61_RS13225 | Genome accession | NZ_CP092554 |
| Coordinates | 2645306..2645980 (-) | Length | 224 a.a. |
| NCBI ID | WP_000866106.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain VMRSA-WC071 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 2637783..2705495 | 2645306..2645980 | within | 0 |
| IScluster/Tn | 2638586..2654216 | 2645306..2645980 | within | 0 |
Gene organization within MGE regions
Location: 2637783..2705495
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI61_RS13165 (MKI61_002610) | - | 2637783..2638079 (-) | 297 | WP_000447709.1 | DUF4176 domain-containing protein | - |
| MKI61_RS13170 (MKI61_002611) | - | 2638067..2638435 (-) | 369 | WP_000066369.1 | hypothetical protein | - |
| MKI61_RS13175 (MKI61_002612) | - | 2638450..2638527 (-) | 78 | Protein_2557 | TIGR04197 family type VII secretion effector | - |
| MKI61_RS13180 (MKI61_002613) | - | 2638586..2639260 (+) | 675 | WP_001105987.1 | IS6-like element IS257 family transposase | - |
| MKI61_RS13185 (MKI61_002614) | aph(3')-IIIa | 2639542..2640336 (-) | 795 | WP_001096887.1 | aminoglycoside O-phosphotransferase APH(3')-IIIa | - |
| MKI61_RS13190 (MKI61_002615) | sat4 | 2640429..2640959 (-) | 531 | WP_000627289.1 | streptothricin N-acetyltransferase Sat4 | - |
| MKI61_RS13195 (MKI61_002616) | - | 2640956..2641591 (-) | 636 | Protein_2561 | aminoglycoside 6-adenylyltransferase | - |
| MKI61_RS13200 (MKI61_002617) | - | 2641732..2642406 (-) | 675 | WP_001105960.1 | IS6 family transposase | - |
| MKI61_RS13205 (MKI61_002618) | - | 2642463..2642639 (-) | 177 | Protein_2563 | undecaprenyl-diphosphate phosphatase | - |
| MKI61_RS13210 (MKI61_002619) | - | 2642653..2643390 (-) | 738 | WP_000369394.1 | ABC transporter permease | - |
| MKI61_RS13215 (MKI61_002620) | - | 2643383..2644312 (-) | 930 | WP_000793446.1 | ABC transporter ATP-binding protein | - |
| MKI61_RS13220 (MKI61_002621) | - | 2644428..2645309 (-) | 882 | Protein_2566 | sensor histidine kinase | - |
| MKI61_RS13225 (MKI61_002622) | braR | 2645306..2645980 (-) | 675 | WP_000866106.1 | response regulator transcription factor | Regulator |
| MKI61_RS13230 (MKI61_002623) | - | 2646120..2646794 (-) | 675 | WP_001105960.1 | IS6 family transposase | - |
| MKI61_RS13235 (MKI61_002624) | - | 2646986..2648398 (-) | 1413 | Protein_2569 | PLP-dependent aminotransferase family protein | - |
| MKI61_RS13240 (MKI61_002625) | - | 2648497..2649468 (+) | 972 | WP_000053810.1 | fatty acid desaturase family protein | - |
| MKI61_RS13245 (MKI61_002626) | - | 2649473..2650093 (+) | 621 | WP_000941203.1 | LysE family transporter | - |
| MKI61_RS13250 (MKI61_002627) | - | 2650137..2650310 (+) | 174 | WP_000044738.1 | hypothetical protein | - |
| MKI61_RS13255 (MKI61_002628) | - | 2650604..2651278 (-) | 675 | WP_001105960.1 | IS6 family transposase | - |
| MKI61_RS13260 (MKI61_002629) | msr(A) | 2651752..2653218 (+) | 1467 | WP_000438874.1 | ABC-F type ribosomal protection protein Msr(A) | - |
| MKI61_RS13265 (MKI61_002630) | - | 2653317..2654216 (+) | 900 | WP_000196698.1 | Mph(C) family macrolide 2'-phosphotransferase | - |
| MKI61_RS13270 (MKI61_002631) | - | 2654701..2655309 (+) | 609 | WP_000635274.1 | recombinase family protein | - |
| MKI61_RS13275 (MKI61_002632) | cadC | 2655581..2655949 (+) | 369 | WP_000726008.1 | Cd(II)/Pb(II)/Zn(II)-sensing metalloregulatory transcriptional repressor CadC | - |
| MKI61_RS13280 (MKI61_002633) | cadA | 2655942..2658125 (+) | 2184 | WP_000003266.1 | cadmium-translocating P-type ATPase CadA | - |
| MKI61_RS13285 (MKI61_002634) | - | 2658265..2658615 (-) | 351 | Protein_2579 | IS6-like element IS257 family transposase | - |
| MKI61_RS13290 (MKI61_002635) | - | 2658685..2659372 (-) | 688 | Protein_2580 | DUF536 domain-containing protein | - |
| MKI61_RS13295 (MKI61_002636) | - | 2659866..2660297 (+) | 432 | Protein_2581 | replication initiator protein A | - |
| MKI61_RS13300 (MKI61_002637) | - | 2660356..2661030 (-) | 675 | WP_001105987.1 | IS6-like element IS257 family transposase | - |
| MKI61_RS13305 (MKI61_002638) | - | 2661062..2661511 (+) | 450 | WP_078071306.1 | ParA family protein | - |
| MKI61_RS13310 (MKI61_002639) | - | 2661514..2661792 (+) | 279 | WP_000774717.1 | hypothetical protein | - |
| MKI61_RS13315 (MKI61_002640) | - | 2661920..2662555 (+) | 636 | Protein_2585 | aminoglycoside 6-adenylyltransferase | - |
| MKI61_RS13320 (MKI61_002641) | sat4 | 2662552..2663082 (+) | 531 | WP_000627289.1 | streptothricin N-acetyltransferase Sat4 | - |
| MKI61_RS13325 (MKI61_002642) | aph(3')-IIIa | 2663175..2663969 (+) | 795 | WP_001096887.1 | aminoglycoside O-phosphotransferase APH(3')-IIIa | - |
| MKI61_RS13330 (MKI61_002643) | - | 2664245..2664787 (+) | 543 | WP_002321977.1 | HTH domain-containing protein | - |
| MKI61_RS13335 (MKI61_002644) | - | 2664817..2665497 (-) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| MKI61_RS13340 (MKI61_002645) | - | 2665572..2665667 (-) | 96 | Protein_2590 | recombinase family protein | - |
| MKI61_RS13345 (MKI61_002646) | - | 2665792..2668779 (+) | 2988 | WP_000343406.1 | Tn3 family transposase | - |
| MKI61_RS13350 (MKI61_002647) | - | 2668928..2669137 (+) | 210 | Protein_2592 | DNA topoisomerase | - |
| MKI61_RS13355 (MKI61_002648) | - | 2669272..2669448 (+) | 177 | Protein_2593 | IS6 family transposase | - |
| MKI61_RS13360 (MKI61_002649) | - | 2669430..2669786 (+) | 357 | WP_029756604.1 | helix-turn-helix domain-containing protein | - |
| MKI61_RS13365 (MKI61_002650) | - | 2670300..2670467 (-) | 168 | WP_005228365.1 | cysteine-rich KTR domain-containing protein | - |
| MKI61_RS13370 (MKI61_002651) | tet(S) | 2670555..2672495 (-) | 1941 | WP_002405437.1 | tetracycline resistance ribosomal protection protein Tet(S) | - |
| MKI61_RS13375 (MKI61_002653) | - | 2673134..2673814 (+) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| MKI61_RS13380 | - | 2674775..2675062 (-) | 288 | WP_242414044.1 | hypothetical protein | - |
| MKI61_RS13385 (MKI61_002655) | - | 2675150..2675524 (-) | 375 | WP_000713874.1 | lactococcin 972 family bacteriocin | - |
| MKI61_RS13390 | - | 2675656..2675814 (+) | 159 | WP_242414045.1 | helix-turn-helix transcriptional regulator | - |
| MKI61_RS13395 (MKI61_002657) | - | 2676633..2677049 (-) | 417 | WP_001232860.1 | hypothetical protein | - |
| MKI61_RS13400 (MKI61_002658) | - | 2677051..2677332 (-) | 282 | WP_000353845.1 | hypothetical protein | - |
| MKI61_RS13405 (MKI61_002659) | - | 2677479..2678159 (+) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| MKI61_RS13410 (MKI61_002660) | - | 2678357..2678962 (+) | 606 | WP_000599739.1 | Fic family protein | - |
| MKI61_RS13415 (MKI61_002661) | - | 2678978..2679550 (+) | 573 | WP_000170424.1 | recombinase family protein | - |
| MKI61_RS13420 (MKI61_002662) | - | 2680023..2680595 (-) | 573 | WP_073120187.1 | IS3 family transposase | - |
| MKI61_RS13430 (MKI61_002665) | - | 2682264..2682518 (-) | 255 | WP_000199136.1 | transposase | - |
| MKI61_RS13435 (MKI61_002666) | prgO | 2682711..2682986 (-) | 276 | WP_001196543.1 | DNA segregation protein PrgO | - |
| MKI61_RS13440 (MKI61_002667) | - | 2682958..2683911 (-) | 954 | WP_000429439.1 | ParA family protein | - |
| MKI61_RS13445 (MKI61_002668) | - | 2684523..2686004 (+) | 1482 | WP_242414046.1 | primase C-terminal domain-containing protein | - |
| MKI61_RS13450 (MKI61_002669) | - | 2686139..2686435 (+) | 297 | WP_000053907.1 | replication control protein PrgN | - |
| MKI61_RS13455 (MKI61_002670) | - | 2686459..2687418 (-) | 960 | WP_000222573.1 | IS30 family transposase | - |
| MKI61_RS13460 (MKI61_002671) | - | 2687601..2688227 (+) | 627 | WP_000833826.1 | hypothetical protein | - |
| MKI61_RS13465 (MKI61_002672) | - | 2688281..2688961 (+) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| MKI61_RS13470 (MKI61_002673) | - | 2689111..2690283 (+) | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| MKI61_RS13475 (MKI61_002674) | aph(2'')-Ia | 2690413..2691851 (-) | 1439 | Protein_2617 | aminoglycoside O-phosphotransferase APH(2'')-Ia | - |
| MKI61_RS13480 (MKI61_002675) | - | 2691852..2692244 (-) | 393 | WP_000393259.1 | GNAT family N-acetyltransferase | - |
| MKI61_RS13485 (MKI61_002676) | - | 2692301..2693350 (-) | 1050 | Protein_2619 | IS256-like element IS256 family transposase | - |
| MKI61_RS13490 (MKI61_002677) | - | 2693417..2694097 (+) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| MKI61_RS13495 (MKI61_002678) | - | 2694151..2694333 (+) | 183 | Protein_2621 | IS6 family transposase | - |
| MKI61_RS13500 (MKI61_002679) | - | 2694543..2695139 (+) | 597 | WP_002296898.1 | replication initiation factor domain-containing protein | - |
| MKI61_RS13505 (MKI61_002681) | - | 2696102..2696395 (+) | 294 | WP_001262780.1 | hypothetical protein | - |
| MKI61_RS13510 (MKI61_002682) | - | 2696429..2697109 (-) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| MKI61_RS13515 (MKI61_002683) | - | 2697240..2697692 (+) | 453 | WP_000751236.1 | hypothetical protein | - |
| MKI61_RS13520 (MKI61_002684) | - | 2697706..2698395 (+) | 690 | WP_000718009.1 | hypothetical protein | - |
| MKI61_RS13525 (MKI61_002685) | - | 2698520..2700871 (+) | 2352 | WP_000344083.1 | glycoside hydrolase domain-containing protein | - |
| MKI61_RS13530 (MKI61_002686) | - | 2700960..2701346 (+) | 387 | WP_000391061.1 | hypothetical protein | - |
| MKI61_RS13535 (MKI61_002687) | - | 2701671..2702288 (+) | 618 | WP_001224538.1 | recombinase family protein | - |
| MKI61_RS13540 (MKI61_002688) | - | 2702329..2702628 (+) | 300 | WP_000366408.1 | BRCT domain-containing protein | - |
| MKI61_RS13545 (MKI61_002689) | - | 2702874..2703371 (-) | 498 | WP_001186972.1 | recombinase family protein | - |
| MKI61_RS13550 (MKI61_002690) | - | 2703413..2704093 (-) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| MKI61_RS13555 (MKI61_002691) | - | 2704110..2704586 (+) | 477 | WP_029756586.1 | recombinase family protein | - |
| MKI61_RS13560 (MKI61_002692) | vanR-A | 2704800..2705495 (+) | 696 | WP_001280781.1 | vancomycin resistance response regulator transcription factor VanR-A | - |
Sequence
Protein
Download Length: 224 a.a. Molecular weight: 25839.93 Da Isoelectric Point: 4.9884
>NTDB_id=658748 MKI61_RS13225 WP_000866106.1 2645306..2645980(-) (braR) [Staphylococcus aureus strain VMRSA-WC071]
MKVLIVEDDLVIGKMLAEELKKWQLEPILIEGFNHVMDAFNTNAPELVLLDINLPAFNGYHWCQEIRKVSTVPIIFISSR
NDSMDQVMAMQMGADDFIEKPFNMTVTITKIQALLRRTYDFTTQVNNLTVDDCELLLDAAKLKFNEETIDLTHTELQIMH
SLFQNKGKFVSRNALIEKCWESEHFIDDNTLAVNITRLRKKLQKLGLTDFIETKKNVGYRVGDV
MKVLIVEDDLVIGKMLAEELKKWQLEPILIEGFNHVMDAFNTNAPELVLLDINLPAFNGYHWCQEIRKVSTVPIIFISSR
NDSMDQVMAMQMGADDFIEKPFNMTVTITKIQALLRRTYDFTTQVNNLTVDDCELLLDAAKLKFNEETIDLTHTELQIMH
SLFQNKGKFVSRNALIEKCWESEHFIDDNTLAVNITRLRKKLQKLGLTDFIETKKNVGYRVGDV
Nucleotide
Download Length: 675 bp
>NTDB_id=658748 MKI61_RS13225 WP_000866106.1 2645306..2645980(-) (braR) [Staphylococcus aureus strain VMRSA-WC071]
ATGAAAGTATTAATCGTAGAGGATGACTTAGTTATCGGGAAGATGCTTGCTGAAGAGCTCAAGAAGTGGCAGCTAGAACC
GATCTTAATAGAAGGTTTCAATCATGTAATGGATGCCTTCAACACGAATGCACCGGAACTTGTGTTACTCGATATTAATT
TACCTGCCTTCAATGGTTATCACTGGTGTCAGGAGATTCGTAAAGTTTCTACTGTACCGATTATATTTATTAGTTCGCGT
AACGACAGTATGGATCAAGTAATGGCGATGCAGATGGGTGCGGATGATTTCATTGAGAAGCCATTTAATATGACTGTTAC
AATTACTAAGATTCAAGCACTATTACGCCGCACGTATGATTTCACCACTCAAGTTAATAATTTAACAGTAGATGATTGCG
AGTTACTACTTGATGCAGCAAAGCTTAAATTTAATGAAGAAACCATAGACCTGACACACACTGAATTGCAAATCATGCAT
AGCTTATTCCAGAACAAGGGCAAATTCGTCAGTCGTAATGCGTTAATCGAAAAATGCTGGGAATCAGAACACTTCATTGA
TGACAATACGCTTGCTGTCAACATTACACGTTTACGCAAAAAGCTACAAAAACTAGGACTTACAGATTTTATCGAAACGA
AGAAAAATGTCGGATATCGTGTAGGTGACGTATGA
ATGAAAGTATTAATCGTAGAGGATGACTTAGTTATCGGGAAGATGCTTGCTGAAGAGCTCAAGAAGTGGCAGCTAGAACC
GATCTTAATAGAAGGTTTCAATCATGTAATGGATGCCTTCAACACGAATGCACCGGAACTTGTGTTACTCGATATTAATT
TACCTGCCTTCAATGGTTATCACTGGTGTCAGGAGATTCGTAAAGTTTCTACTGTACCGATTATATTTATTAGTTCGCGT
AACGACAGTATGGATCAAGTAATGGCGATGCAGATGGGTGCGGATGATTTCATTGAGAAGCCATTTAATATGACTGTTAC
AATTACTAAGATTCAAGCACTATTACGCCGCACGTATGATTTCACCACTCAAGTTAATAATTTAACAGTAGATGATTGCG
AGTTACTACTTGATGCAGCAAAGCTTAAATTTAATGAAGAAACCATAGACCTGACACACACTGAATTGCAAATCATGCAT
AGCTTATTCCAGAACAAGGGCAAATTCGTCAGTCGTAATGCGTTAATCGAAAAATGCTGGGAATCAGAACACTTCATTGA
TGACAATACGCTTGCTGTCAACATTACACGTTTACGCAAAAAGCTACAAAAACTAGGACTTACAGATTTTATCGAAACGA
AGAAAAATGTCGGATATCGTGTAGGTGACGTATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| braR | Staphylococcus aureus N315 |
66.516 |
98.661 |
0.656 |