Detailed information NTG0657886

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MKD48_RS04415
• Genome accession: NZ_CP092475
• Coordinates: 854311..855354 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain P5
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 849311..860354

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MKD48_RS04385	-	849739..849849 (+)	111	WP_248313597.1	hypothetical protein	-
MKD48_RS04390	-	849878..850291 (+)	414	WP_001670387.1	hypothetical protein	-
MKD48_RS04395	-	850722..851708 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
MKD48_RS04400	map	852237..852995 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MKD48_RS04405	-	853212..853598 (+)	387	WP_001110179.1	hypothetical protein	-
MKD48_RS04410	liaF	853613..854314 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MKD48_RS04415	vraS	854311..855354 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MKD48_RS04420	vraR	855344..855973 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MKD48_RS04425	-	856086..857303 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
MKD48_RS04430	-	857581..857856 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
MKD48_RS04435	-	857863..858327 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MKD48_RS04440	-	858474..858674 (+)	201	WP_000180460.1	DUF1128 family protein	-
MKD48_RS04445	-	858677..859933 (+)	1257	WP_075583716.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=657886 MKD48_RS04415 WP_001017131.1 854311..855354(+) (vraS) [Staphylococcus aureus strain P5]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=657886 MKD48_RS04415 WP_001017131.1 854311..855354(+) (vraS) [Staphylococcus aureus strain P5]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1