Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HP1CH_RS04180 Genome accession   NZ_AP013355
Coordinates   873020..874804 (+) Length   594 a.a.
NCBI ID   WP_000774319.1    Uniprot ID   A0AAC8SBE8
Organism   Helicobacter pylori 26695-1CH     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 868020..879804
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HP1CH_RS04150 motB 868784..869557 (+) 774 WP_001085308.1 flagellar motor protein MotB -
  HP1CH_RS04155 - 869554..870000 (+) 447 WP_001081241.1 hypothetical protein -
  HP1CH_RS04160 - 870069..871730 (+) 1662 WP_000901317.1 glycine betaine ABC transporter substrate-binding protein -
  HP1CH_RS04165 - 871734..872384 (+) 651 WP_000659451.1 ATP-binding cassette domain-containing protein -
  HP1CH_RS04170 - 872387..872566 (-) 180 WP_000468790.1 hypothetical protein -
  HP1CH_RS04175 - 872558..873019 (+) 462 WP_000437145.1 hypothetical protein -
  HP1CH_RS04180 uvrC 873020..874804 (+) 1785 WP_000774319.1 excinuclease ABC subunit UvrC Machinery gene
  HP1CH_RS04185 - 874815..876080 (+) 1266 WP_000746824.1 homoserine dehydrogenase -
  HP1CH_RS04190 - 876081..876425 (+) 345 WP_001211699.1 YraN family protein -
  HP1CH_RS04195 trxA 876514..876834 (+) 321 WP_000020199.1 thioredoxin -
  HP1CH_RS04200 trxB 876839..877774 (+) 936 WP_000564420.1 thioredoxin-disulfide reductase -
  HP1CH_RS04205 - 877990..878811 (+) 822 WP_001262061.1 glycosyltransferase family 25 protein -
  HP1CH_RS04210 - 879017..879265 (-) 249 WP_001244602.1 RNA-binding protein -
  HP1CH_RS09105 - 879419..879610 (+) 192 Protein_800 hypothetical protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68679.95 Da        Isoelectric Point: 9.7128

>NTDB_id=65648 HP1CH_RS04180 WP_000774319.1 873020..874804(+) (uvrC) [Helicobacter pylori 26695-1CH]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACIFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHSSSQCVGGMVVYENNAFQKNSYRRYHLKGSDEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=65648 HP1CH_RS04180 WP_000774319.1 873020..874804(+) (uvrC) [Helicobacter pylori 26695-1CH]
ATGGCTGATTTATTGTCCAGTTTAAAAAACCTTCCTAACAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCCATCCGCAATAATGAAATCACGCCCA
ATCATCGCGCCAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAACTCTTTAATCAAGCAGCTCAAACCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTGGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATTTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAGGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAATAAAGCGGT
GTTAGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCAGAACAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCTCACCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGACAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTAGAAATCTTTGACACA
AGCCACCATTCTAGCAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAACGCCTTCCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTGATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCACAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTGGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

100

100

1

Multiple sequence alignment