Detailed information NTG0652123

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: L4X60_RS00445
• Genome accession: NZ_CP091525
• Coordinates: 81562..82605 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain N09CSA16
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76562..87605

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L4X60_RS00415 (L4X60_00415)	-	76988..77098 (+)	111	WP_001790257.1	hypothetical protein	-
L4X60_RS00420 (L4X60_00420)	-	77127..77540 (+)	414	WP_001557448.1	hypothetical protein	-
L4X60_RS00425 (L4X60_00425)	-	77971..78957 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
L4X60_RS00430 (L4X60_00430)	map	79488..80246 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
L4X60_RS00435 (L4X60_00435)	-	80463..80849 (+)	387	WP_001110179.1	hypothetical protein	-
L4X60_RS00440 (L4X60_00440)	liaF	80864..81565 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
L4X60_RS00445 (L4X60_00445)	vraS	81562..82605 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
L4X60_RS00450 (L4X60_00450)	vraR	82595..83224 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
L4X60_RS00455 (L4X60_00455)	-	83337..84554 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
L4X60_RS00460 (L4X60_00460)	-	84832..85107 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
L4X60_RS00465 (L4X60_00465)	-	85114..85578 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
L4X60_RS00470 (L4X60_00470)	-	85725..85925 (+)	201	WP_000180460.1	DUF1128 family protein	-
L4X60_RS00475 (L4X60_00475)	-	85928..87184 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=652123 L4X60_RS00445 WP_001017131.1 81562..82605(+) (vraS) [Staphylococcus aureus strain N09CSA16]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=652123 L4X60_RS00445 WP_001017131.1 81562..82605(+) (vraS) [Staphylococcus aureus strain N09CSA16]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1