Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   L5471_RS10040 Genome accession   NZ_CP091523
Coordinates   2037235..2038584 (+) Length   449 a.a.
NCBI ID   WP_002454341.1    Uniprot ID   -
Organism   Staphylococcus aureus strain N12HSA28     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2031738..2047001 2037235..2038584 within 0


Gene organization within MGE regions


Location: 2031738..2047001
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L5471_RS10020 (L5471_10020) - 2031738..2033228 (-) 1491 WP_000554504.1 RNA-binding domain-containing protein -
  L5471_RS10025 (L5471_10025) - 2033736..2034785 (-) 1050 WP_249452158.1 ACP synthase -
  L5471_RS10030 (L5471_10030) - 2034924..2035214 (+) 291 WP_001036438.1 hypothetical protein -
  L5471_RS10035 (L5471_10035) - 2035214..2037001 (+) 1788 WP_249452159.1 DUF927 domain-containing protein -
  L5471_RS10040 (L5471_10040) ccrA 2037235..2038584 (+) 1350 WP_002454341.1 recombinase family protein Machinery gene
  L5471_RS10045 (L5471_10045) ccrB 2038606..2040234 (+) 1629 WP_002511343.1 recombinase family protein Machinery gene
  L5471_RS10050 (L5471_10050) - 2040758..2041108 (+) 351 WP_002454344.1 SAUGI family uracil-DNA glycosylase inhibitor -
  L5471_RS10055 (L5471_10055) - 2041195..2041506 (+) 312 WP_001631033.1 DUF960 domain-containing protein -
  L5471_RS10060 (L5471_10060) - 2041521..2042027 (+) 507 WP_001092189.1 DUF1643 domain-containing protein -
  L5471_RS10065 (L5471_10065) - 2042079..2043686 (+) 1608 Protein_1945 IS1182 family transposase -
  L5471_RS10070 (L5471_10070) - 2043677..2043937 (-) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  L5471_RS10075 (L5471_10075) - 2043909..2044895 (-) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  L5471_RS10080 (L5471_10080) mecA 2044992..2047001 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52717.58 Da        Isoelectric Point: 10.0679

>NTDB_id=652112 L5471_RS10040 WP_002454341.1 2037235..2038584(+) (ccrA) [Staphylococcus aureus strain N12HSA28]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYRVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEKDDTFINRQPYQVRNIIMNPNYCGRVINQYGQFDNMFPSIVSANV
YEQAQRLRLQKQTKRTPSDNQLKQKIKCPYCNATLTNMTVRKKNHILRYYVCPKNLNASRFVCDFKGINAQTLEDKVLKV
CQDFYQDHHIYAKIKNAIDKRLKRQRNTETHHTLTQEKLIEKLAQGIIDAETFRKQMQSLHQQPQRITSISEHQIQHTIQ
NIIQKRFTLNILYPYIETIHIAKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=652112 L5471_RS10040 WP_002454341.1 2037235..2038584(+) (ccrA) [Staphylococcus aureus strain N12HSA28]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACACAATTAATTCAACAAGGACAATGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
TTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATATCGTGTTCATATCTTAAGTGTGCATGATGGTTATTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGACTATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGCCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAAAAGATGATACGTTCATCAATCGACAACCTTATCAAGTTCGTAATATTATCATGA
ACCCTAATTATTGTGGTCGTGTTATCAACCAATACGGTCAATTCGACAATATGTTCCCTTCTATTGTTTCAGCAAATGTA
TATGAACAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACGGACACCTTCCGATAATCAACTTAAACAAAAAATCAA
ATGCCCATATTGTAATGCAACACTTACAAATATGACCGTTAGAAAAAAGAATCATATATTACGTTACTACGTCTGTCCTA
AAAACTTGAATGCTTCACGCTTTGTCTGTGATTTCAAAGGCATCAATGCACAGACATTGGAAGATAAAGTATTAAAAGTG
TGCCAAGACTTTTATCAAGACCACCATATCTACGCAAAAATTAAAAATGCGATTGACAAACGCTTAAAAAGACAACGAAA
CACAGAAACACATCACACACTGACTCAAGAAAAACTAATAGAAAAGTTAGCCCAAGGCATCATCGATGCAGAAACGTTCA
GAAAACAAATGCAATCATTACATCAACAACCGCAACGCATCACATCCATCAGTGAGCATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTGAACATATTGTACCCCTATATTGAAACCATTCACATTGCGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCAATTGCATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(169-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

91.759

100

0.918
  ccrA Staphylococcus aureus COL

74.833

100

0.748