Detailed information NTG0652079

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: L5471_RS00460
• Genome accession: NZ_CP091523
• Coordinates: 82747..83790 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain N12HSA28
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77747..88790

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L5471_RS00430 (L5471_00430)	-	78228..78339 (+)	112	Protein_85	hypothetical protein	-
L5471_RS00435 (L5471_00435)	-	78368..78781 (+)	414	WP_001837236.1	hypothetical protein	-
L5471_RS00440 (L5471_00440)	-	79271..80257 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
L5471_RS00445 (L5471_00445)	map	80673..81431 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
L5471_RS00450 (L5471_00450)	-	81648..82034 (+)	387	WP_001110179.1	hypothetical protein	-
L5471_RS00455 (L5471_00455)	liaF	82049..82750 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
L5471_RS00460 (L5471_00460)	vraS	82747..83790 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
L5471_RS00465 (L5471_00465)	vraR	83780..84409 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
L5471_RS00470 (L5471_00470)	-	84521..85732 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
L5471_RS00475 (L5471_00475)	-	86010..86285 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
L5471_RS00480 (L5471_00480)	-	86292..86756 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
L5471_RS00485 (L5471_00485)	-	86903..87103 (+)	201	WP_000180460.1	DUF1128 family protein	-
L5471_RS00490 (L5471_00490)	-	87106..88362 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=652079 L5471_RS00460 WP_001017131.1 82747..83790(+) (vraS) [Staphylococcus aureus strain N12HSA28]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=652079 L5471_RS00460 WP_001017131.1 82747..83790(+) (vraS) [Staphylococcus aureus strain N12HSA28]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1