Detailed information NTG0065189

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SPYJRS4_RS05765
• Genome accession: NZ_AP012335
• Coordinates: 1161895..1162932 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes JRS4
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1156895..1167932

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYJRS4_RS05745 (SPYJRS4_1205)	-	1157644..1158270 (+)	627	WP_011184760.1	A24 family peptidase	-
SPYJRS4_RS05750 (SPYJRS4_1206)	rlmN	1158352..1159431 (-)	1080	WP_011184761.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
SPYJRS4_RS05755 (SPYJRS4_1207)	-	1159435..1160055 (-)	621	WP_002992791.1	YutD family protein	-
SPYJRS4_RS05760 (SPYJRS4_1209)	-	1160503..1161479 (-)	977	Protein_1108	LacI family DNA-binding transcriptional regulator	-
SPYJRS4_RS05765 (SPYJRS4_1211)	sepM	1161895..1162932 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
SPYJRS4_RS05770 (SPYJRS4_1212)	coaD	1162919..1163410 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
SPYJRS4_RS05775 (SPYJRS4_1213)	rsmD	1163400..1163939 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SPYJRS4_RS05780 (SPYJRS4_1214)	asnA	1164062..1165054 (-)	993	WP_011184764.1	aspartate--ammonia ligase	-
SPYJRS4_RS05785 (SPYJRS4_1215)	arcC	1165367..1166317 (-)	951	WP_011018011.1	carbamate kinase	-
SPYJRS4_RS05790 (SPYJRS4_1216)	-	1166337..1167668 (-)	1332	WP_011184765.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=65189 SPYJRS4_RS05765 WP_010922499.1 1161895..1162932(-) (sepM) [Streptococcus pyogenes JRS4]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=65189 SPYJRS4_RS05765 WP_010922499.1 1161895..1162932(-) (sepM) [Streptococcus pyogenes JRS4]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693