Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SPYJRS4_RS04375 Genome accession   NZ_AP012335
Coordinates   886544..887218 (+) Length   224 a.a.
NCBI ID   WP_002984519.1    Uniprot ID   -
Organism   Streptococcus pyogenes JRS4     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 881544..892218
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYJRS4_RS04360 (SPYJRS4_0906) pstB 881977..882735 (+) 759 WP_002993892.1 phosphate ABC transporter ATP-binding protein PstB -
  SPYJRS4_RS04365 (SPYJRS4_0907) phoU 882803..883456 (+) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  SPYJRS4_RS04370 (SPYJRS4_0908) - 883661..886198 (+) 2538 WP_021340544.1 M1 family metallopeptidase -
  SPYJRS4_RS04375 (SPYJRS4_0909) ciaR 886544..887218 (+) 675 WP_002984519.1 response regulator transcription factor Regulator
  SPYJRS4_RS04380 (SPYJRS4_0910) ciaH 887211..888521 (+) 1311 WP_011184551.1 HAMP domain-containing sensor histidine kinase Regulator
  SPYJRS4_RS04385 (SPYJRS4_0911) rpsT 888646..888894 (-) 249 WP_009881183.1 30S ribosomal protein S20 -
  SPYJRS4_RS04390 (SPYJRS4_0912) coaA 888948..889868 (-) 921 WP_010922353.1 type I pantothenate kinase -
  SPYJRS4_RS04395 (SPYJRS4_0913) - 890136..890729 (+) 594 WP_002989699.1 class I SAM-dependent methyltransferase -
  SPYJRS4_RS04400 (SPYJRS4_0914) - 891383..891772 (+) 390 WP_002984531.1 cytidine deaminase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25703.91 Da        Isoelectric Point: 4.7287

>NTDB_id=65182 SPYJRS4_RS04375 WP_002984519.1 886544..887218(+) (ciaR) [Streptococcus pyogenes JRS4]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=65182 SPYJRS4_RS04375 WP_002984519.1 886544..887218(+) (ciaR) [Streptococcus pyogenes JRS4]
ATGATAAAGATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TCGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366

Multiple sequence alignment