Detailed information NTG0651370

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: L3475_RS10860
• Genome accession: NZ_CP091451
• Coordinates: 2097771..2098523 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 3238/09
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2092771..2103523

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L3475_RS10830 (L3475_10750)	-	2093150..2095702 (+)	2553	WP_000834680.1	YfhO family protein	-
L3475_RS11030	-	2095732..2096806 (-)	1075	Protein_2102	YhgE/Pip family protein	-
L3475_RS10845 (L3475_10765)	-	2096986..2097528 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
L3475_RS10860 (L3475_10780)	comE	2097771..2098523 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
L3475_RS10865 (L3475_10785)	comD/comD1	2098520..2099845 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
L3475_RS10870 (L3475_10790)	comC/comC1	2099866..2099991 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
L3475_RS10880 (L3475_10800)	rlmH	2100273..2100752 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
L3475_RS10885 (L3475_10805)	htrA	2100935..2102116 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
L3475_RS10890 (L3475_10810)	spo0J	2102174..2102932 (+)	759	WP_000410376.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=651370 L3475_RS10860 WP_000866065.1 2097771..2098523(-) (comE) [Streptococcus pneumoniae strain 3238/09]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=651370 L3475_RS10860 WP_000866065.1 2097771..2098523(-) (comE) [Streptococcus pneumoniae strain 3238/09]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408