Detailed information NTG0650508

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: OG996_RS20265
• Genome accession: NZ_CP107971
• Coordinates: 4431757..4434285 (-)
• Length: 842 a.a.
• NCBI ID: WP_266519022.1
• Uniprot ID: -
• Organism: Streptomyces sp. NBC_00366
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 4426757..4439285

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OG996_RS20240 (OG996_20240)	-	4426798..4427229 (-)	432	WP_266519030.1	helix-turn-helix transcriptional regulator	-
OG996_RS20245 (OG996_20245)	-	4427337..4428917 (-)	1581	WP_266519029.1	MDR family MFS transporter	-
OG996_RS20250 (OG996_20250)	-	4429042..4429653 (+)	612	WP_266519028.1	TetR/AcrR family transcriptional regulator	-
OG996_RS20255 (OG996_20255)	-	4429680..4430387 (-)	708	WP_328550200.1	M23 family metallopeptidase	-
OG996_RS20260 (OG996_20260)	-	4431024..4431623 (+)	600	WP_266519024.1	HAD family acid phosphatase	-
OG996_RS20265 (OG996_20265)	clpC	4431757..4434285 (-)	2529	WP_266519022.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
OG996_RS20270 (OG996_20270)	-	4434727..4435326 (+)	600	WP_266519020.1	SCO3374 family protein	-
OG996_RS20275 (OG996_20275)	-	4435335..4435670 (-)	336	WP_266519018.1	Lsr2 family protein	-
OG996_RS20280 (OG996_20280)	-	4435991..4436542 (-)	552	WP_266519016.1	amino-acid N-acetyltransferase	-
OG996_RS20285 (OG996_20285)	-	4436552..4436983 (-)	432	WP_266519013.1	BlaI/MecI/CopY family transcriptional regulator	-
OG996_RS20290 (OG996_20290)	-	4437137..4437316 (-)	180	WP_266519011.1	hypothetical protein	-
OG996_RS20295 (OG996_20295)	-	4437389..4438048 (-)	660	WP_266592430.1	hypothetical protein	-
OG996_RS20300 (OG996_20300)	-	4438178..4438975 (-)	798	WP_266519009.1	type III pantothenate kinase	-

Sequence

Protein

• Length: 842 a.a.
• Molecular weight: 92891.95 Da
• Isoelectric Point: 5.7459

>NTDB_id=650508 OG996_RS20265 WP_266519022.1 4431757..4434285(-) (clpC) [Streptomyces sp. NBC_00366]
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKALESLGISLEAVRQQVEEIIGQGQQAPSGHIPF
TPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLSGYQGKETAGASGGPAEG
TPSTSLVLDQFGRNLTQAARESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVKGEVPETLK
DKHLYTLDLGALVAGSRYRGDFEERLKKVLKEIRTRGDIILFIDELHTLVGAGAAEGAIDAASILKPMLARGELQTIGAT
TLDEYRKHLEKDAALERRFQPIQVAEPSLPHTIEILKGLRDRYEAHHRVSITDEALVQAATLADRYISDRFLPDKAIDLI
DEAGSRMRIRRMTAPPDLREFDEKIAGVRRDKESAIDSQDFEKAASLRDKEKQLLAAKAKREKEWKAGDMDVVAEVDGEL
IAEVLATATGIPVFKLTEEESSRLLRMEDELHKRVIGQVDAVKALSKAIRRTRAGLKDPKRPGGSFIFAGPSGVGKTELS
KALAEFLFGDEDALISLDMSEFSEKHTVSRLFGSPPGYVGYEEGGQLTEKVRRKPFSVVLFDEVEKAHPDIFNSLLQILE
DGRLTDSQGRVVDFKNTVIIMTTNLGTRDISKGFNLGFAAAGDTKSNYERMKNKVSDELKQHFRPEFLNRVDDVVVFPQL
TQADILSIVDLMVAKVDERLKDRDMGIELSQSAKELLSTKGYDQVLGARPLRRTIQREIEDTLSEKILFGELRPGHIVVV
DTEGEGETQTFTFRGEEKSALPDAPPIEQAAGGAGPNLSKEA

Nucleotide

• Length: 2529 bp

>NTDB_id=650508 OG996_RS20265 WP_266519022.1 4431757..4434285(-) (clpC) [Streptomyces sp. NBC_00366]
ATGTTCGAGAGGTTCACCGACCGCGCGCGGCGGGTTGTCGTCCTGGCTCAGGAAGAAGCCCGGATGCTCAACCACAACTA
CATCGGCACCGAGCACATCCTCCTGGGCCTGATCCACGAGGGTGAGGGTGTCGCCGCCAAGGCCCTTGAGAGCCTCGGGA
TTTCGCTCGAGGCGGTCCGCCAGCAGGTGGAGGAGATCATCGGCCAGGGCCAGCAGGCCCCGTCCGGGCACATCCCCTTC
ACCCCCCGTGCCAAGAAGGTCCTGGAGCTGTCGCTCCGGGAGGCCCTTCAGCTGGGCCACAACTACATCGGCACGGAGCA
CATCCTGCTCGGCCTGATCCGTGAGGGCGAGGGCGTCGCCGCCCAGGTCCTGGTCAAGCTGGGTGCCGATCTCAACCGGG
TGCGGCAGCAGGTCATCCAGCTGCTCTCCGGTTACCAGGGCAAGGAGACCGCCGGCGCCAGTGGCGGCCCTGCCGAGGGC
ACCCCCTCGACGTCCCTGGTCCTCGACCAGTTCGGCCGGAACCTCACCCAGGCCGCTCGTGAGTCCAAGCTCGACCCGGT
CATCGGGCGCGAGAAGGAGATCGAGCGGGTCATGCAGGTGCTGTCCCGCCGTACCAAGAACAACCCGGTCCTGATCGGTG
AGCCCGGCGTCGGCAAGACCGCCGTCGTCGAAGGCCTCGCCCAGGCCATCGTCAAGGGCGAGGTGCCCGAGACCCTCAAG
GACAAGCACCTCTACACCCTGGACCTCGGCGCGCTGGTCGCCGGCTCCCGCTACCGCGGTGACTTCGAGGAGCGCCTGAA
GAAGGTCCTCAAGGAGATCCGCACCCGCGGCGACATCATCCTGTTCATCGACGAGCTGCACACGCTGGTCGGTGCGGGTG
CCGCCGAGGGCGCCATCGACGCCGCTTCGATCCTGAAGCCGATGCTGGCCCGCGGTGAGCTGCAGACCATCGGCGCCACC
ACGCTGGACGAGTACCGCAAGCATCTGGAGAAGGACGCCGCCCTCGAGCGCCGCTTCCAGCCCATCCAGGTCGCCGAGCC
GTCCCTGCCGCACACGATCGAGATCCTCAAGGGTCTGCGCGACCGGTACGAGGCCCACCACCGCGTCTCCATCACGGACG
AGGCGCTGGTCCAGGCCGCCACACTGGCCGACCGGTACATCTCGGACCGCTTCCTGCCGGACAAGGCGATCGACCTGATC
GACGAGGCCGGTTCCCGGATGCGCATCCGCCGGATGACCGCGCCGCCGGACCTGCGCGAGTTCGACGAGAAGATCGCGGG
CGTGCGCCGCGACAAGGAGTCCGCGATCGACTCGCAGGACTTCGAGAAGGCCGCCTCCCTCCGCGACAAGGAGAAGCAGC
TCCTGGCCGCCAAGGCCAAGCGGGAGAAGGAGTGGAAGGCCGGCGACATGGACGTCGTCGCCGAGGTCGACGGCGAGCTG
ATCGCCGAGGTCCTCGCCACGGCCACCGGCATCCCGGTCTTCAAGCTGACCGAGGAGGAGTCCTCGCGTCTGCTGCGCAT
GGAGGACGAGCTCCACAAGCGGGTCATCGGCCAGGTCGACGCCGTCAAGGCGCTGTCGAAGGCGATCCGTCGTACGCGTG
CGGGCCTCAAGGACCCGAAGCGCCCCGGTGGCTCGTTCATCTTCGCCGGCCCGTCCGGTGTCGGTAAGACCGAGCTGTCC
AAGGCCCTCGCCGAGTTCCTCTTCGGTGACGAGGACGCGCTGATCTCCCTCGACATGTCGGAGTTCAGCGAGAAGCACAC
GGTGTCGCGTCTCTTCGGTTCGCCCCCCGGATACGTGGGCTACGAAGAGGGCGGCCAGCTGACCGAGAAGGTCCGCCGCA
AGCCGTTCTCCGTCGTCCTGTTCGACGAGGTCGAGAAGGCCCACCCGGACATCTTCAACTCGCTGCTGCAGATCCTGGAG
GACGGTCGTCTGACCGACTCCCAGGGCCGGGTCGTGGACTTCAAGAACACGGTCATCATCATGACGACCAACCTCGGCAC
CCGGGACATCTCCAAGGGCTTCAACCTGGGCTTCGCGGCCGCGGGTGACACCAAGTCCAACTACGAGCGCATGAAGAACA
AGGTCTCGGACGAGCTCAAGCAGCACTTCCGCCCCGAGTTCCTCAACCGCGTCGACGACGTGGTCGTCTTCCCGCAGCTG
ACCCAGGCCGACATCCTCTCGATCGTCGACCTGATGGTGGCCAAGGTGGACGAGCGCCTCAAGGACCGGGACATGGGCAT
CGAGCTCTCCCAGTCCGCCAAGGAGCTGCTGTCCACCAAGGGTTACGACCAGGTGCTGGGTGCGCGTCCGCTGCGTCGCA
CCATCCAGCGCGAGATCGAGGACACGCTGTCGGAGAAGATCCTCTTCGGCGAGCTGCGTCCCGGTCACATTGTGGTCGTC
GACACGGAGGGCGAGGGCGAGACCCAGACCTTCACCTTCCGCGGCGAGGAGAAGTCGGCGCTGCCCGACGCCCCGCCGAT
CGAGCAGGCCGCGGGTGGGGCAGGACCCAACCTGAGCAAGGAGGCGTGA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (542-713)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (720-800)

• ATPase family associated with various cellular activities (AAA) (AAA) (210-330)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (93-142)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (16-68)

• AAA lid domain (AAA_lid_9) (350-450)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	61.519	95.368	0.587
clpC	Streptococcus mutans UA159	44.578	98.575	0.439
clpC	Streptococcus thermophilus LMD-9	42.891	99.406	0.426
clpC	Streptococcus thermophilus LMG 18311	42.721	99.525	0.425
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	43.596	96.437	0.42
clpC	Streptococcus pneumoniae Rx1	43.875	95.012	0.417
clpC	Streptococcus pneumoniae D39	43.875	95.012	0.417
clpC	Streptococcus pneumoniae TIGR4	43.899	94.418	0.414
clpE	Streptococcus mutans UA159	53.834	74.347	0.4
clpC	Lactococcus lactis subsp. cremoris KW2	50.602	78.86	0.399
clpE	Streptococcus pneumoniae TIGR4	52.97	73.99	0.392
clpE	Streptococcus pneumoniae R6	52.809	73.99	0.391
clpE	Streptococcus pneumoniae D39	52.809	73.99	0.391
clpE	Streptococcus pneumoniae Rx1	52.809	73.99	0.391