Detailed information NTG0064957

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: H020_RS0109900
• Genome accession: NZ_AKVY01000001
• Coordinates: 1876783..1877820 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae TIGR4
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1871783..1882820

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H020_RS0109875	-	1872584..1873915 (-)	1332	WP_000390039.1	hemolysin family protein	-
H020_RS0109880	endA	1874144..1874968 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
H020_RS0109885	-	1875007..1875195 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
H020_RS0109890	murA	1875188..1876471 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
H020_RS0109895	-	1876495..1876725 (-)	231	WP_000250384.1	DUF1146 family protein	-
H020_RS0109900	sepM	1876783..1877820 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
H020_RS0109905	coaD	1877804..1878292 (-)	489	WP_001280753.1	pantetheine-phosphate adenylyltransferase	-
H020_RS0109910	rsmD	1878282..1878821 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
H020_RS0109915	asnA	1878886..1879878 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
H020_RS0109925	-	1879990..1880673 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
H020_RS0109930	-	1880729..1881469 (-)	741	WP_000152703.1	TrmH family RNA methyltransferase	-
H020_RS0109935	-	1881503..1881781 (+)	279	WP_001174612.1	acylphosphatase	-
H020_RS0109940	yidC	1881859..1882785 (+)	927	WP_000835955.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=64957 H020_RS0109900 WP_000727277.1 1876783..1877820(-) (sepM) [Streptococcus pneumoniae TIGR4]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=64957 H020_RS0109900 WP_000727277.1 1876783..1877820(-) (sepM) [Streptococcus pneumoniae TIGR4]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591