Detailed information NTG0647457

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: L1O91_RS09560
• Genome accession: NZ_CP091066
• Coordinates: 1953715..1954758 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UMCG579
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1948715..1959758

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L1O91_RS09530 (L1O91_09530)	-	1949139..1950395 (-)	1257	WP_257552941.1	aminopeptidase	-
L1O91_RS09535 (L1O91_09535)	-	1950398..1950598 (-)	201	WP_000180460.1	DUF1128 family protein	-
L1O91_RS09540 (L1O91_09540)	-	1950745..1951209 (+)	465	WP_054189636.1	low molecular weight protein-tyrosine-phosphatase	-
L1O91_RS09545 (L1O91_09545)	-	1951216..1951491 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
L1O91_RS09550 (L1O91_09550)	-	1951769..1952986 (+)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
L1O91_RS09555 (L1O91_09555)	vraR	1953096..1953725 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
L1O91_RS09560 (L1O91_09560)	vraS	1953715..1954758 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
L1O91_RS09565 (L1O91_09565)	liaF	1954755..1955456 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
L1O91_RS09570 (L1O91_09570)	-	1955471..1955857 (-)	387	WP_001110179.1	hypothetical protein	-
L1O91_RS09575 (L1O91_09575)	map	1956074..1956832 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
L1O91_RS09580 (L1O91_09580)	-	1957650..1958636 (+)	987	WP_054189634.1	aromatic acid exporter family protein	-
L1O91_RS09585 (L1O91_09585)	-	1959145..1959558 (-)	414	WP_077446671.1	hypothetical protein	-
L1O91_RS09590 (L1O91_09590)	-	1959587..1959697 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=647457 L1O91_RS09560 WP_001017131.1 1953715..1954758(-) (vraS) [Staphylococcus aureus strain UMCG579]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=647457 L1O91_RS09560 WP_001017131.1 1953715..1954758(-) (vraS) [Staphylococcus aureus strain UMCG579]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTTATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACGGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACAAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTCCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCACTTGGTTTAAAAG
ACAAATCATTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1