Detailed information NTG0647093

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KB224_RS04335
• Genome accession: NZ_CP091006
• Coordinates: 923958..925004 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain R10C
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 918958..930004

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KB224_RS04310 (KB224_04310)	isaB	920099..920635 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
KB224_RS04315 (KB224_04315)	-	920786..921772 (-)	987	WP_002457091.1	FUSC family protein	-
KB224_RS04320 (KB224_04320)	map	921946..922701 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
KB224_RS04325 (KB224_04325)	-	922859..923245 (+)	387	WP_001830382.1	hypothetical protein	-
KB224_RS04330 (KB224_04330)	liaF	923260..923961 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
KB224_RS04335 (KB224_04335)	vraS	923958..925004 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
KB224_RS04340 (KB224_04340)	vraR	924994..925623 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
KB224_RS04345 (KB224_04345)	-	925680..926858 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
KB224_RS04350 (KB224_04350)	-	927265..927549 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
KB224_RS04355 (KB224_04355)	-	927557..928021 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
KB224_RS04360 (KB224_04360)	-	928162..928377 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
KB224_RS04365 (KB224_04365)	-	928379..929620 (+)	1242	WP_235063542.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=647093 KB224_RS04335 WP_001830374.1 923958..925004(+) (vraS) [Staphylococcus epidermidis strain R10C]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=647093 KB224_RS04335 WP_001830374.1 923958..925004(+) (vraS) [Staphylococcus epidermidis strain R10C]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92