Detailed information NTG0646971

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KB226_RS07360
• Genome accession: NZ_CP090985
• Coordinates: 1515547..1516593 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 50D
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1510547..1521593

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KB226_RS07330 (KB226_07330)	-	1510931..1512172 (-)	1242	WP_001832467.1	aminopeptidase	-
KB226_RS07335 (KB226_07335)	-	1512174..1512389 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
KB226_RS07340 (KB226_07340)	-	1512530..1512994 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
KB226_RS07345 (KB226_07345)	-	1513002..1513286 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
KB226_RS07350 (KB226_07350)	-	1513693..1514871 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
KB226_RS07355 (KB226_07355)	vraR	1514928..1515557 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
KB226_RS07360 (KB226_07360)	vraS	1515547..1516593 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
KB226_RS07365 (KB226_07365)	liaF	1516590..1517291 (-)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
KB226_RS07370 (KB226_07370)	-	1517306..1517692 (-)	387	WP_001830382.1	hypothetical protein	-
KB226_RS07375 (KB226_07375)	map	1517850..1518605 (-)	756	WP_001830397.1	type I methionyl aminopeptidase	-
KB226_RS07380 (KB226_07380)	-	1518779..1519765 (+)	987	WP_002457091.1	FUSC family protein	-
KB226_RS07385 (KB226_07385)	isaB	1519916..1520452 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=646971 KB226_RS07360 WP_001830374.1 1515547..1516593(-) (vraS) [Staphylococcus epidermidis strain 50D]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=646971 KB226_RS07360 WP_001830374.1 1515547..1516593(-) (vraS) [Staphylococcus epidermidis strain 50D]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92