Detailed information NTG0646437

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KB229_RS04390
• Genome accession: NZ_CP090915
• Coordinates: 931274..932320 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 45A5
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 926274..937320

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KB229_RS04365 (KB229_04365)	isaB	927415..927951 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
KB229_RS04370 (KB229_04370)	-	928102..929088 (-)	987	WP_001830388.1	FUSC family protein	-
KB229_RS04375 (KB229_04375)	map	929262..930017 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
KB229_RS04380 (KB229_04380)	-	930175..930561 (+)	387	WP_001830382.1	hypothetical protein	-
KB229_RS04385 (KB229_04385)	liaF	930576..931277 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
KB229_RS04390 (KB229_04390)	vraS	931274..932320 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
KB229_RS04395 (KB229_04395)	vraR	932310..932939 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
KB229_RS04400 (KB229_04400)	-	932996..934174 (-)	1179	WP_234966384.1	YihY/virulence factor BrkB family protein	-
KB229_RS04405 (KB229_04405)	-	934581..934865 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
KB229_RS04410 (KB229_04410)	-	934873..935337 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
KB229_RS04415 (KB229_04415)	-	935478..935693 (+)	216	WP_234966385.1	DUF1128 domain-containing protein	-
KB229_RS04420 (KB229_04420)	-	935695..936936 (+)	1242	WP_234966387.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=646437 KB229_RS04390 WP_001830374.1 931274..932320(+) (vraS) [Staphylococcus epidermidis strain 45A5]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=646437 KB229_RS04390 WP_001830374.1 931274..932320(+) (vraS) [Staphylococcus epidermidis strain 45A5]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92