Detailed information NTG0646404

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KB228_RS04105
• Genome accession: NZ_CP090912
• Coordinates: 886909..887955 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 44
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 881909..892955

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KB228_RS04080 (KB228_04080)	isaB	883050..883586 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
KB228_RS04085 (KB228_04085)	-	883737..884723 (-)	987	WP_001830388.1	FUSC family protein	-
KB228_RS04090 (KB228_04090)	map	884897..885652 (+)	756	WP_234963960.1	type I methionyl aminopeptidase	-
KB228_RS04095 (KB228_04095)	-	885810..886196 (+)	387	WP_001830382.1	hypothetical protein	-
KB228_RS04100 (KB228_04100)	liaF	886211..886912 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
KB228_RS04105 (KB228_04105)	vraS	886909..887955 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
KB228_RS04110 (KB228_04110)	vraR	887945..888574 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
KB228_RS04115 (KB228_04115)	-	888631..889809 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
KB228_RS04120 (KB228_04120)	-	890216..890500 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
KB228_RS04125 (KB228_04125)	-	890508..890972 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
KB228_RS04130 (KB228_04130)	-	891113..891328 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
KB228_RS04135 (KB228_04135)	-	891330..892571 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=646404 KB228_RS04105 WP_001830374.1 886909..887955(+) (vraS) [Staphylococcus epidermidis strain 44]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=646404 KB228_RS04105 WP_001830374.1 886909..887955(+) (vraS) [Staphylococcus epidermidis strain 44]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92