Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   L1A12_RS05755 Genome accession   NZ_CP090882
Coordinates   1151161..1151865 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain CH2241     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1146161..1156865
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L1A12_RS05725 (L1A12_05725) - 1146342..1147328 (+) 987 WP_000204733.1 L-lactate dehydrogenase -
  L1A12_RS05730 (L1A12_05730) - 1147629..1148372 (-) 744 Protein_1142 ion channel -
  L1A12_RS05735 (L1A12_05735) - 1148419..1148673 (-) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  L1A12_RS05740 (L1A12_05740) - 1148675..1148917 (-) 243 WP_000208080.1 DUF6290 family protein -
  L1A12_RS05745 (L1A12_05745) vicX 1149008..1149817 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  L1A12_RS05750 (L1A12_05750) micB 1149819..1151168 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  L1A12_RS05755 (L1A12_05755) micA 1151161..1151865 (-) 705 WP_000722076.1 response regulator YycF Regulator
  L1A12_RS05760 (L1A12_05760) mutY 1151920..1153095 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  L1A12_RS05765 (L1A12_05765) - 1153424..1155094 (-) 1671 WP_000845287.1 formate--tetrahydrofolate ligase -
  L1A12_RS05770 (L1A12_05770) coaB 1155324..1156013 (+) 690 WP_000699489.1 phosphopantothenate--cysteine ligase -
  L1A12_RS05775 (L1A12_05775) coaC 1156025..1156576 (+) 552 WP_001284130.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=645601 L1A12_RS05755 WP_000722076.1 1151161..1151865(-) (micA) [Streptococcus pneumoniae strain CH2241]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=645601 L1A12_RS05755 WP_000722076.1 1151161..1151865(-) (micA) [Streptococcus pneumoniae strain CH2241]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38