Detailed information NTG0645438

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: L1A06_RS10680
• Genome accession: NZ_CP090877
• Coordinates: 2176607..2177650 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SAUR_BFS11
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2171607..2182650

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L1A06_RS10650 (L1A06_10650)	-	2171974..2172084 (+)	111	WP_001790257.1	hypothetical protein	-
L1A06_RS10655 (L1A06_10655)	-	2172113..2172526 (+)	414	WP_001566709.1	hypothetical protein	-
L1A06_RS10660 (L1A06_10660)	-	2173016..2174002 (-)	987	WP_000999713.1	FUSC family protein	-
L1A06_RS10665 (L1A06_10665)	map	2174533..2175291 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
L1A06_RS10670 (L1A06_10670)	-	2175508..2175894 (+)	387	WP_001110179.1	hypothetical protein	-
L1A06_RS10675 (L1A06_10675)	liaF	2175909..2176610 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
L1A06_RS10680 (L1A06_10680)	vraS	2176607..2177650 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
L1A06_RS10685 (L1A06_10685)	vraR	2177640..2178269 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
L1A06_RS10690 (L1A06_10690)	-	2178381..2179598 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
L1A06_RS10695 (L1A06_10695)	-	2179876..2180151 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
L1A06_RS10700 (L1A06_10700)	-	2180158..2180622 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
L1A06_RS10705 (L1A06_10705)	-	2180769..2180969 (+)	201	WP_000180460.1	DUF1128 family protein	-
L1A06_RS10710 (L1A06_10710)	-	2180972..2182228 (+)	1257	WP_072419726.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=645438 L1A06_RS10680 WP_001017131.1 2176607..2177650(+) (vraS) [Staphylococcus aureus strain SAUR_BFS11]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=645438 L1A06_RS10680 WP_001017131.1 2176607..2177650(+) (vraS) [Staphylococcus aureus strain SAUR_BFS11]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGCATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1