Detailed information NTG0644953

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LL229_RS05465
• Genome accession: NZ_CP090823
• Coordinates: 1014690..1015382 (+)
• Length: 230 a.a.
• NCBI ID: WP_003130756.1
• Uniprot ID: S6EZK2
• Organism: Lactococcus lactis subsp. lactis strain 229
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1009690..1020382

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LL229_RS05435 (LL229_1692)	-	1010652..1011488 (+)	837	WP_003130766.1	metallophosphoesterase	-
LL229_RS05440 (LL229_1691)	-	1011549..1012079 (+)	531	WP_003130764.1	CHAP domain-containing protein	-
LL229_RS05445 (LL229_1690)	-	1012564..1012926 (+)	363	WP_010906050.1	TIGR02328 family protein	-
LL229_RS05450 (LL229_1689)	-	1013008..1013472 (+)	465	WP_003130761.1	hypothetical protein	-
LL229_RS05455 (LL229_1688)	-	1013628..1013873 (+)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
LL229_RS05460 (LL229_1687)	-	1014004..1014534 (+)	531	WP_003130758.1	DUF177 domain-containing protein	-
LL229_RS05465 (LL229_1686)	covR	1014690..1015382 (+)	693	WP_003130756.1	response regulator transcription factor	Regulator
LL229_RS05470 (LL229_1685)	covS	1015390..1016865 (+)	1476	WP_010906048.1	HAMP domain-containing histidine kinase	Regulator
LL229_RS05475 (LL229_1684)	-	1017048..1018289 (+)	1242	WP_003130753.1	ammonium transporter	-
LL229_RS05480 (LL229_1683)	-	1018421..1018762 (+)	342	WP_010906046.1	P-II family nitrogen regulator	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26684.36 Da
• Isoelectric Point: 5.1273

>NTDB_id=644953 LL229_RS05465 WP_003130756.1 1014690..1015382(+) (covR) [Lactococcus lactis subsp. lactis strain 229]
MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=644953 LL229_RS05465 WP_003130756.1 1014690..1015382(+) (covR) [Lactococcus lactis subsp. lactis strain 229]
ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG
CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCCCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG
ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT
TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT
CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACAGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG
TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA
GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: S6EZK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361