Detailed information NTG0642133

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LZ183_RS10310
• Genome accession: NZ_CP090407
• Coordinates: 2095090..2096133 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GD4SA159-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2090090..2101133

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LZ183_RS10280 (LZ183_10260)	-	2090511..2091767 (-)	1257	WP_074347694.1	aminopeptidase	-
LZ183_RS10285 (LZ183_10265)	-	2091770..2091970 (-)	201	WP_000180460.1	DUF1128 family protein	-
LZ183_RS10290 (LZ183_10270)	-	2092117..2092581 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LZ183_RS10295 (LZ183_10275)	-	2092588..2092863 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
LZ183_RS10300 (LZ183_10280)	-	2093141..2094358 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
LZ183_RS10305 (LZ183_10285)	vraR	2094471..2095100 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
LZ183_RS10310 (LZ183_10290)	vraS	2095090..2096133 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LZ183_RS10315 (LZ183_10295)	liaF	2096130..2096831 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LZ183_RS10320 (LZ183_10300)	-	2096846..2097232 (-)	387	WP_001110182.1	hypothetical protein	-
LZ183_RS10325 (LZ183_10305)	map	2097449..2098207 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
LZ183_RS10330 (LZ183_10310)	-	2098791..2099777 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
LZ183_RS10335 (LZ183_10315)	-	2099966..2100379 (-)	414	WP_078064776.1	hypothetical protein	-
LZ183_RS10340 (LZ183_10320)	-	2100408..2100518 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=642133 LZ183_RS10310 WP_001017131.1 2095090..2096133(-) (vraS) [Staphylococcus aureus strain GD4SA159-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=642133 LZ183_RS10310 WP_001017131.1 2095090..2096133(-) (vraS) [Staphylococcus aureus strain GD4SA159-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1