Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   LZ183_RS00180 Genome accession   NZ_CP090407
Coordinates   44083..45432 (-) Length   449 a.a.
NCBI ID   WP_216347504.1    Uniprot ID   -
Organism   Staphylococcus aureus strain GD4SA159-1     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 40746..92248 44083..45432 within 0
SCCmec 42910..55072 44083..45432 within 0


Gene organization within MGE regions


Location: 40746..92248
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LZ183_RS00165 (LZ183_00165) - 41224..41535 (-) 312 WP_000700850.1 DUF960 family protein -
  LZ183_RS00170 (LZ183_00170) - 41628..41969 (-) 342 WP_000859158.1 SAUGI family uracil-DNA glycosylase inhibitor -
  LZ183_RS00175 (LZ183_00175) ccrB 42436..44061 (-) 1626 WP_257238251.1 recombinase family protein Machinery gene
  LZ183_RS00180 (LZ183_00180) ccrA 44083..45432 (-) 1350 WP_216347504.1 recombinase family protein Machinery gene
  LZ183_RS00185 (LZ183_00185) - 45624..45899 (-) 276 WP_044466491.1 hypothetical protein -
  LZ183_RS00190 (LZ183_00190) - 45968..47755 (-) 1788 WP_044466492.1 DUF927 domain-containing protein -
  LZ183_RS00195 (LZ183_00195) - 47881..49308 (-) 1428 WP_259489399.1 DUF6038 family protein -
  LZ183_RS00200 (LZ183_00200) - 49733..50407 (-) 675 WP_001105987.1 IS6-like element IS257 family transposase -
  LZ183_RS00205 (LZ183_00205) - 50491..50832 (+) 342 WP_001797647.1 hydroxymethylglutaryl-CoA synthase -
  LZ183_RS00210 (LZ183_00210) - 51749..52492 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  LZ183_RS00215 (LZ183_00215) - 52589..53017 (+) 429 WP_000872606.1 MaoC family dehydratase -
  LZ183_RS00220 (LZ183_00220) mecA 53063..55072 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  LZ183_RS00225 (LZ183_00225) - 55169..55276 (+) 108 Protein_42 beta-lactam sensor/signal transducer MecR1 -
  LZ183_RS00230 (LZ183_00230) - 55317..55991 (+) 675 WP_001105987.1 IS6-like element IS257 family transposase -
  LZ183_RS00235 (LZ183_00235) - 56051..56527 (-) 477 Protein_44 integrase DNA-binding domain-containing protein -
  LZ183_RS00240 (LZ183_00240) - 56609..56812 (-) 204 WP_000814511.1 excisionase -
  LZ183_RS00245 (LZ183_00245) - 56796..57047 (+) 252 WP_001845478.1 hypothetical protein -
  LZ183_RS00250 (LZ183_00250) - 57273..57503 (-) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  LZ183_RS00255 (LZ183_00255) - 57500..57922 (-) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  LZ183_RS00260 (LZ183_00260) - 58427..58780 (+) 354 WP_001227347.1 helix-turn-helix transcriptional regulator -
  LZ183_RS00265 (LZ183_00265) - 58840..59007 (-) 168 WP_000336323.1 cysteine-rich KTR domain-containing protein -
  LZ183_RS00270 (LZ183_00270) tet(M) 59126..61045 (-) 1920 WP_000691736.1 tetracycline resistance ribosomal protection protein Tet(M) -
  LZ183_RS00275 (LZ183_00275) - 61061..61177 (-) 117 WP_001791010.1 tetracycline resistance determinant leader peptide -
  LZ183_RS00280 (LZ183_00280) - 61422..62357 (-) 936 WP_001224320.1 conjugal transfer protein -
  LZ183_RS00285 (LZ183_00285) - 62354..63351 (-) 998 Protein_54 bifunctional lysozyme/C40 family peptidase -
  LZ183_RS00290 (LZ183_00290) - 63348..65525 (-) 2178 WP_000804748.1 membrane protein -
  LZ183_RS00295 (LZ183_00295) - 65528..67966 (-) 2439 Protein_56 ATP-binding protein -
  LZ183_RS00300 (LZ183_00300) - 67950..68342 (-) 393 WP_000723888.1 conjugal transfer protein -
  LZ183_RS00305 (LZ183_00305) - 68431..68928 (-) 498 WP_000342539.1 antirestriction protein ArdA -
  LZ183_RS00310 (LZ183_00310) - 69045..69266 (-) 222 WP_001009056.1 hypothetical protein -
  LZ183_RS00315 (LZ183_00315) mobT 69309..70514 (-) 1206 WP_000398284.1 MobT family relaxase -
  LZ183_RS00320 (LZ183_00320) - 70537..70689 (-) 153 WP_000879507.1 hypothetical protein -
  LZ183_RS00325 (LZ183_00325) - 70692..72077 (-) 1386 WP_000813488.1 FtsK/SpoIIIE domain-containing protein -
  LZ183_RS00330 (LZ183_00330) - 72106..72492 (-) 387 WP_000985015.1 YdcP family protein -
  LZ183_RS00335 (LZ183_00335) - 72508..72822 (-) 315 WP_000420682.1 YdcP family protein -
  LZ183_RS00340 (LZ183_00340) - 73153..73725 (+) 573 WP_151362627.1 ADP-ribosyltransferase -
  LZ183_RS00345 (LZ183_00345) - 73996..74613 (+) 618 WP_069826417.1 CadD family cadmium resistance transporter -
  LZ183_RS00350 (LZ183_00350) - 74632..74973 (+) 342 WP_151362628.1 metalloregulator ArsR/SmtB family transcription factor -
  LZ183_RS00355 (LZ183_00355) dfrG 75273..75770 (+) 498 WP_000868795.1 trimethoprim-resistant dihydrofolate reductase DfrG -
  LZ183_RS00360 (LZ183_00360) - 75842..77794 (-) 1953 WP_000163792.1 hypothetical protein -
  LZ183_RS00365 (LZ183_00365) - 77801..78037 (-) 237 WP_001159903.1 hypothetical protein -
  LZ183_RS00370 (LZ183_00370) arsC 78278..78679 (-) 402 WP_151362629.1 arsenate reductase (thioredoxin) -
  LZ183_RS00375 (LZ183_00375) arsB 78697..79989 (-) 1293 WP_204172539.1 arsenite efflux transporter membrane subunit ArsB -
  LZ183_RS00380 (LZ183_00380) - 79986..80303 (-) 318 WP_011274435.1 metalloregulator ArsR/SmtB family transcription factor -
  LZ183_RS00385 (LZ183_00385) - 80572..82632 (+) 2061 WP_025905371.1 heavy metal translocating P-type ATPase -
  LZ183_RS00390 (LZ183_00390) - 82650..83195 (+) 546 WP_037537668.1 YdhK family protein -
  LZ183_RS00395 (LZ183_00395) - 83644..84771 (+) 1128 WP_113587714.1 hypothetical protein -
  LZ183_RS00400 (LZ183_00400) - 84790..86304 (+) 1515 WP_113587716.1 class I SAM-dependent DNA methyltransferase -
  LZ183_RS00405 (LZ183_00405) - 86294..87619 (+) 1326 WP_113587718.1 restriction endonuclease subunit S -
  LZ183_RS00410 (LZ183_00410) - 87603..90725 (+) 3123 WP_113587720.1 type I restriction endonuclease subunit R -
  LZ183_RS00415 (LZ183_00415) - 90923..91423 (-) 501 WP_241563771.1 hypothetical protein -
  LZ183_RS00420 (LZ183_00420) - 91443..92057 (-) 615 WP_113587722.1 hypothetical protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52287.87 Da        Isoelectric Point: 9.9621

>NTDB_id=642096 LZ183_RS00180 WP_216347504.1 44083..45432(-) (ccrA) [Staphylococcus aureus strain GD4SA159-1]
MKQAIGYLRQSTLKQQSLAAQKQTIKALAEKHSIQHITFYSDKQSGRTDKRNGYQQVTELIQQGQCNVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKAKQGKLITTHAPFGYHYH
NGTFTIDTVKSPTVKAVFNYYLQGYGYKKIAQYLEADDKFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVTRTQKQVKRKPSENQLKQKIKCPYCHSTLTNMTVRKPDHSLRYYVCPQNMNSARFVCEFKGINAQELETSVLAT
CQNFFQNQQLYSKINHTIQQRLKRQRDVETKTTLNHEQLIEKLAQGKIDAETFREQTQSLHQQSKPLSSISAYQIRKAFQ
NIIQERFTLNMLYPYIDEINISKNKTLAGIYFKNEPLNIVNQTTQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=642096 LZ183_RS00180 WP_216347504.1 44083..45432(-) (ccrA) [Staphylococcus aureus strain GD4SA159-1]
ATGAAACAAGCAATTGGTTACTTACGTCAAAGTACACTCAAACAACAATCTCTAGCAGCACAGAAACAGACCATCAAAGC
ACTAGCCGAAAAACACAGTATTCAACACATTACCTTTTATAGCGATAAGCAATCAGGACGCACTGATAAGCGAAATGGTT
ATCAACAAGTTACTGAACTGATTCAACAAGGACAATGTAACGTATTATGTTGCTATCGTCTAAATCGACTTCATCGTAAT
TTGAAAAATGCATTAAAACTCATGAAATTGTGTCAAAAATACCATGTCCATATCTTAAGCGTTCATGATGGCTACTTCGA
CATGGATAAAGCATTCGATCGGCTCAAACTCAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAAACAAGGTAAACTGATTACAACACATGCACCCTTTGGGTATCACTATCAT
AATGGTACTTTCACGATAGACACAGTAAAATCACCAACAGTAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCTCAATACTTAGAAGCTGATGATAAATTCATTAATCGCAAGCCCTATCAAGTACGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTACCCGAACTCAGAAACAAGTCAAACGTAAGCCGTCAGAAAATCAACTCAAACAAAAAATCAA
ATGTCCCTATTGTCATTCGACACTCACAAACATGACTGTCCGAAAACCAGATCATTCATTGCGTTACTATGTCTGTCCGC
AAAATATGAATAGCGCTCGCTTTGTTTGTGAATTTAAAGGAATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGACT
TGTCAGAACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TGTAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGGCAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACATCAACAATCAAAACCTCTATCATCAATCAGTGCGTATCAAATTCGAAAAGCTTTCCAA
AACATCATTCAAGAACGTTTCACGCTAAACATGTTGTACCCCTATATTGATGAAATTAATATTTCTAAAAACAAAACCCT
TGCGGGGATCTATTTCAAAAATGAACCTCTAAACATTGTCAATCAAACTACGCAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(170-249)

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

93.318

100

0.933
  ccrA Staphylococcus aureus N315

75.056

100

0.751