Detailed information NTG0640002

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LV622_RS09520
• Genome accession: NZ_CP090001
• Coordinates: 1935150..1936193 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RN6390
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1930150..1941193

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LV622_RS09490 (LV622_09490)	-	1930568..1931824 (-)	1257	WP_001795438.1	aminopeptidase	-
LV622_RS09495 (LV622_09495)	-	1931827..1932027 (-)	201	WP_000180461.1	DUF1128 family protein	-
LV622_RS09500 (LV622_09500)	-	1932174..1932638 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LV622_RS09505 (LV622_09505)	-	1932645..1932920 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
LV622_RS09510 (LV622_09510)	-	1933198..1934415 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
LV622_RS09515 (LV622_09515)	vraR	1934531..1935160 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
LV622_RS09520 (LV622_09520)	vraS	1935150..1936193 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LV622_RS09525 (LV622_09525)	liaF	1936190..1936891 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LV622_RS09530 (LV622_09530)	-	1936906..1937292 (-)	387	WP_001110179.1	hypothetical protein	-
LV622_RS09535 (LV622_09535)	map	1937509..1938267 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LV622_RS09540 (LV622_09540)	-	1938795..1939781 (+)	987	WP_000999713.1	FUSC family protein	-
LV622_RS09545 (LV622_09545)	-	1940212..1940625 (-)	414	WP_001549145.1	hypothetical protein	-
LV622_RS09550 (LV622_09550)	-	1940654..1940764 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=640002 LV622_RS09520 WP_001017131.1 1935150..1936193(-) (vraS) [Staphylococcus aureus strain RN6390]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=640002 LV622_RS09520 WP_001017131.1 1935150..1936193(-) (vraS) [Staphylococcus aureus strain RN6390]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1