Detailed information NTG0638122

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LUU82_RS00460
• Genome accession: NZ_CP089586
• Coordinates: 82471..83514 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain E1185_IV_ST12
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77471..88514

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LUU82_RS00430 (LUU82_00430)	-	77956..78066 (+)	111	WP_001790257.1	hypothetical protein	-
LUU82_RS00435 (LUU82_00435)	-	78095..78508 (+)	414	WP_001566709.1	hypothetical protein	-
LUU82_RS00440 (LUU82_00440)	-	78939..79925 (-)	987	WP_000999713.1	FUSC family protein	-
LUU82_RS00445 (LUU82_00445)	map	80397..81155 (+)	759	WP_000636138.1	type I methionyl aminopeptidase	-
LUU82_RS00450 (LUU82_00450)	-	81372..81758 (+)	387	WP_001110179.1	hypothetical protein	-
LUU82_RS00455 (LUU82_00455)	liaF	81773..82474 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LUU82_RS00460 (LUU82_00460)	vraS	82471..83514 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LUU82_RS00465 (LUU82_00465)	vraR	83504..84133 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
LUU82_RS00470 (LUU82_00470)	-	84245..85462 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
LUU82_RS00475 (LUU82_00475)	-	85740..86015 (-)	276	WP_000428171.1	hypothetical protein	-
LUU82_RS00480 (LUU82_00480)	-	86022..86486 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LUU82_RS00485 (LUU82_00485)	-	86633..86833 (+)	201	WP_000180460.1	DUF1128 family protein	-
LUU82_RS00490 (LUU82_00490)	-	86836..88092 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=638122 LUU82_RS00460 WP_001017131.1 82471..83514(+) (vraS) [Staphylococcus aureus strain E1185_IV_ST12]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=638122 LUU82_RS00460 WP_001017131.1 82471..83514(+) (vraS) [Staphylococcus aureus strain E1185_IV_ST12]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1