Detailed information NTG0637706

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: LUY96_RS10685
• Genome accession: NZ_CP089502
• Coordinates: 2120184..2121533 (+)
• Length: 449 a.a.
• NCBI ID: WP_061731575.1
• Uniprot ID: B4F4B7
• Organism: Staphylococcus aureus strain 3488_VV_ ST8
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2116610..2143399	2120184..2121533	within	0

Gene organization within MGE regions

Location: 2116610..2143399

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LUY96_RS10675	-	2116610..2118040 (+)	1431	WP_001008608.1	DUF6038 family protein	-
LUY96_RS10680	cch1	2118160..2119950 (+)	1791	WP_061731576.1	cassette chromosome replicative helicase	-
LUY96_RS10685	ccrA	2120184..2121533 (+)	1350	WP_061731575.1	cassette chromosome recombinase CcrA	Machinery gene
LUY96_RS10690	ccrB	2121555..2123183 (+)	1629	WP_001186602.1	cassette chromosome recombinase CcrB	Machinery gene
LUY96_RS10695	-	2123701..2124051 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
LUY96_RS10700	-	2124138..2124449 (+)	312	WP_000700853.1	DUF960 family protein	-
LUY96_RS10705	-	2124467..2124973 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
LUY96_RS10710	-	2124994..2125311 (+)	318	WP_000659050.1	JAB domain-containing protein	-
LUY96_RS10715	-	2125430..2126515 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
LUY96_RS10720	-	2126512..2128404 (+)	1893	WP_001557544.1	site-specific integrase	-
LUY96_RS10725	-	2128411..2128788 (+)	378	WP_000361059.1	DUF6262 family protein	-
LUY96_RS10730	-	2128939..2129721 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
LUY96_RS10735	erm(A)	2129847..2130578 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
LUY96_RS10740	-	2130661..2130720 (-)	60	WP_010959190.1	erythromycin resistance leader peptide	-
LUY96_RS10745	-	2131112..2131774 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
LUY96_RS10750	-	2132119..2132757 (-)	639	Protein_2079	sulfite exporter TauE/SafE family protein	-
LUY96_RS10755	cstR	2132757..2133017 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
LUY96_RS10760	-	2133153..2134217 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
LUY96_RS10765	cstB	2134250..2135584 (+)	1335	Protein_2082	persulfide dioxygenase-sulfurtransferase CstB	-
LUY96_RS10770	-	2135698..2136828 (-)	1131	WP_010922808.1	ROK family transcriptional regulator	-
LUY96_RS10775	psm-mec	2137162..2137230 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
LUY96_RS10780	-	2137315..2137422 (-)	108	Protein_2085	BlaI/MecI/CopY family transcriptional regulator	-
LUY96_RS10785	-	2137576..2139180 (+)	1605	WP_000284571.1	IS1182-like element IS1182 family transposase	-
LUY96_RS10790	-	2139285..2139536 (-)	252	Protein_2087	BlaI/MecI/CopY family transcriptional regulator	-
LUY96_RS10795	mecR1	2139536..2141293 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
LUY96_RS10800	mecA	2141390..2143399 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52557.24 Da
• Isoelectric Point: 9.9150

>NTDB_id=637706 LUY96_RS10685 WP_061731575.1 2120184..2121533(+) (ccrA) [Staphylococcus aureus strain 3488_VV_ ST8]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVKNGLQEKAKQGQLITTHAPFGYDYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIMNPNYCGRVINQYGQFDNMFPSIVSANV
YEQAQRLRLQKQTKQTSSDNQLKQKIKCPCCNATLTNMTVRKKNHILRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=637706 LUY96_RS10685 WP_061731575.1 2120184..2121533(+) (ccrA) [Staphylococcus aureus strain 3488_VV_ ST8]
ATGAAACAAGTTATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACTTATCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCAGATAATATTGGAGAAC
AAGTCAAAAATGGCCTTCAAGAAAAGGCAAAACAAGGTCAATTGATTACAACACATGCGCCTTTTGGTTACGACTATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGCCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCTTATCAAGTTCGTAATATTATCATGA
ACCCTAATTATTGTGGTCGTGTTATCAACCAATACGGTCAATTCGACAATATGTTCCCTTCTATTGTTTCAGCAAATGTA
TATGAACAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCGTTAGAAAAAAGAATCATATATTACGTTACTACGTCTGTCCTA
AAAATATGAATGCTTCACGCTTTGTCTGTGATTTCAAAGGCATCAATGCACAGACATTGGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Resolvase, N terminal domain (Resolvase) (4-147)

• Recombinase (Recombinase) (169-248)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-321)

3D structure

• AlphaFold DB: B4F4B7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	96.659	100	0.967
ccrA	Staphylococcus aureus COL	75.056	100	0.751