Detailed information NTG0637673

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LUY96_RS00475
• Genome accession: NZ_CP089502
• Coordinates: 85649..86692 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 3488_VV_ ST8
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 80649..91692

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LUY96_RS00445	-	81019..81129 (+)	111	WP_001790257.1	hypothetical protein	-
LUY96_RS00450	-	81158..81571 (+)	414	WP_001549145.1	hypothetical protein	-
LUY96_RS00455	-	82002..82988 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
LUY96_RS00460	map	83575..84333 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LUY96_RS00465	-	84550..84936 (+)	387	WP_001110179.1	hypothetical protein	-
LUY96_RS00470	liaF	84951..85652 (+)	702	WP_001622130.1	cell wall-active antibiotics response protein LiaF	-
LUY96_RS00475	vraS	85649..86692 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LUY96_RS00480	vraR	86682..87311 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
LUY96_RS00485	-	87427..88644 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
LUY96_RS00490	-	88922..89197 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
LUY96_RS00495	-	89204..89668 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LUY96_RS00500	-	89815..90015 (+)	201	WP_000180461.1	DUF1128 family protein	-
LUY96_RS00505	-	90018..91274 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=637673 LUY96_RS00475 WP_001017131.1 85649..86692(+) (vraS) [Staphylococcus aureus strain 3488_VV_ ST8]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=637673 LUY96_RS00475 WP_001017131.1 85649..86692(+) (vraS) [Staphylococcus aureus strain 3488_VV_ ST8]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTACATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1