Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   LUZ00_RS00260 Genome accession   NZ_CP089498
Coordinates   58874..60223 (-) Length   449 a.a.
NCBI ID   WP_061731575.1    Uniprot ID   B4F4B7
Organism   Staphylococcus aureus strain M03/0073_III_ST239     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 43510..63797 58874..60223 within 0


Gene organization within MGE regions


Location: 43510..63797
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LUZ00_RS00185 mecA 43510..45519 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  LUZ00_RS00190 mecR1 45616..47373 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  LUZ00_RS00195 - 47373..47624 (+) 252 Protein_36 BlaI/MecI/CopY family transcriptional regulator -
  LUZ00_RS00200 - 47729..49333 (-) 1605 WP_000284571.1 IS1182-like element IS1182 family transposase -
  LUZ00_RS00205 - 49712..49771 (+) 60 WP_010959190.1 erythromycin resistance leader peptide -
  LUZ00_RS00210 erm(A) 49829..50560 (+) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  LUZ00_RS00215 - 50686..51468 (-) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  LUZ00_RS00220 - 51619..51996 (-) 378 WP_000361059.1 DUF6262 family protein -
  LUZ00_RS00225 - 52003..53895 (-) 1893 WP_049291207.1 site-specific integrase -
  LUZ00_RS00230 - 53892..54977 (-) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  LUZ00_RS00235 - 55096..55413 (-) 318 WP_000659050.1 JAB domain-containing protein -
  LUZ00_RS00240 - 55434..55940 (-) 507 WP_001092169.1 DUF1643 domain-containing protein -
  LUZ00_RS00245 - 55958..56269 (-) 312 WP_000700853.1 DUF960 family protein -
  LUZ00_RS00250 - 56356..56706 (-) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  LUZ00_RS00255 ccrB 57224..58852 (-) 1629 WP_001186602.1 cassette chromosome recombinase CcrB Machinery gene
  LUZ00_RS00260 ccrA 58874..60223 (-) 1350 WP_061731575.1 cassette chromosome recombinase CcrA Machinery gene
  LUZ00_RS00265 cch1 60457..62247 (-) 1791 WP_061731576.1 cassette chromosome replicative helicase -
  LUZ00_RS00270 - 62367..63797 (-) 1431 WP_001008608.1 DUF6038 family protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52557.24 Da        Isoelectric Point: 9.9150

>NTDB_id=637590 LUZ00_RS00260 WP_061731575.1 58874..60223(-) (ccrA) [Staphylococcus aureus strain M03/0073_III_ST239]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVKNGLQEKAKQGQLITTHAPFGYDYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIMNPNYCGRVINQYGQFDNMFPSIVSANV
YEQAQRLRLQKQTKQTSSDNQLKQKIKCPCCNATLTNMTVRKKNHILRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=637590 LUZ00_RS00260 WP_061731575.1 58874..60223(-) (ccrA) [Staphylococcus aureus strain M03/0073_III_ST239]
ATGAAACAAGTTATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACTTATCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCAGATAATATTGGAGAAC
AAGTCAAAAATGGCCTTCAAGAAAAGGCAAAACAAGGTCAATTGATTACAACACATGCGCCTTTTGGTTACGACTATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGCCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCTTATCAAGTTCGTAATATTATCATGA
ACCCTAATTATTGTGGTCGTGTTATCAACCAATACGGTCAATTCGACAATATGTTCCCTTCTATTGTTTCAGCAAATGTA
TATGAACAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCGTTAGAAAAAAGAATCATATATTACGTTACTACGTCTGTCCTA
AAAATATGAATGCTTCACGCTTTGTCTGTGATTTCAAAGGCATCAATGCACAGACATTGGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(169-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B4F4B7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

96.659

100

0.967
  ccrA Staphylococcus aureus COL

75.056

100

0.751