Detailed information NTG0637438

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LUZ02_RS11385
• Genome accession: NZ_CP089491
• Coordinates: 2361214..2362257 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 0242_IV_ST30
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2356214..2367257

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LUZ02_RS11355	-	2356642..2356752 (+)	111	WP_001790257.1	hypothetical protein	-
LUZ02_RS11360	-	2356781..2357194 (+)	414	WP_001670387.1	hypothetical protein	-
LUZ02_RS11365	-	2357625..2358611 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
LUZ02_RS11370	map	2359140..2359898 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LUZ02_RS11375	-	2360115..2360501 (+)	387	WP_001110179.1	hypothetical protein	-
LUZ02_RS11380	liaF	2360516..2361217 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LUZ02_RS11385	vraS	2361214..2362257 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LUZ02_RS11390	vraR	2362247..2362876 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
LUZ02_RS11395	-	2362989..2364206 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
LUZ02_RS11400	-	2364484..2364759 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
LUZ02_RS11405	-	2364766..2365230 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LUZ02_RS11410	-	2365377..2365577 (+)	201	WP_000180460.1	DUF1128 family protein	-
LUZ02_RS11415	-	2365580..2366836 (+)	1257	WP_075583716.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=637438 LUZ02_RS11385 WP_001017131.1 2361214..2362257(+) (vraS) [Staphylococcus aureus strain 0242_IV_ST30]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=637438 LUZ02_RS11385 WP_001017131.1 2361214..2362257(+) (vraS) [Staphylococcus aureus strain 0242_IV_ST30]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1