Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   LUZ08_RS14450 Genome accession   NZ_CP089489
Coordinates   2894040..2894756 (-) Length   238 a.a.
NCBI ID   WP_000688492.1    Uniprot ID   A0A7U7IEW1
Organism   Staphylococcus aureus strain E1174_IV_ST22     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2889040..2899756
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LUZ08_RS14430 - 2890134..2891084 (+) 951 WP_407535432.1 LacI family DNA-binding transcriptional regulator -
  LUZ08_RS14435 - 2891233..2892717 (+) 1485 WP_000141417.1 sucrose-6-phosphate hydrolase -
  LUZ08_RS14440 - 2892714..2893673 (+) 960 WP_001253312.1 carbohydrate kinase -
  LUZ08_RS14445 - 2893861..2893968 (-) 108 WP_001790167.1 hypothetical protein -
  LUZ08_RS14450 agrA 2894040..2894756 (-) 717 WP_000688492.1 quorum-sensing response regulator AgrA Regulator
  LUZ08_RS14455 agrC 2894775..2896066 (-) 1292 Protein_2810 quorum-sensing sensor histidine kinase AgrC -
  LUZ08_RS14460 agrD 2896091..2896231 (-) 141 WP_001093929.1 cyclic lactone autoinducer peptide AgrD -
  LUZ08_RS14465 agrB 2896228..2896797 (-) 570 WP_001105707.1 accessory gene regulator AgrB -
  LUZ08_RS14470 hld 2897087..2897167 (+) 81 WP_000046022.1 delta-hemolysin -
  LUZ08_RS14475 - 2897764..2898549 (-) 786 WP_000867960.1 carbon-nitrogen family hydrolase -
  LUZ08_RS14480 - 2898901..2899527 (-) 627 WP_000522384.1 nitroreductase family protein -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27905.90 Da        Isoelectric Point: 6.0927

>NTDB_id=637412 LUZ08_RS14450 WP_000688492.1 2894040..2894756(-) (agrA) [Staphylococcus aureus strain E1174_IV_ST22]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=637412 LUZ08_RS14450 WP_000688492.1 2894040..2894756(-) (agrA) [Staphylococcus aureus strain E1174_IV_ST22]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACCTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCTGAATTAAGAACTCGAATTATAGACTGTTTAGAAACTGCACATACACGCTTACAATTGT
TGTCTAAAGATAATAGCGTTGAAACGATTGAATTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTTAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATAG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-120)

LytTr DNA-binding domain (LytTR)

(151-237)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7U7IEW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

100

100

1