Detailed information NTG0637371

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LUZ08_RS00470
• Genome accession: NZ_CP089489
• Coordinates: 82430..83473 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain E1174_IV_ST22
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77430..88473

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LUZ08_RS00440	-	77860..77970 (+)	111	WP_001790257.1	hypothetical protein	-
LUZ08_RS00445	-	77999..78412 (+)	414	WP_001549145.1	hypothetical protein	-
LUZ08_RS00450	-	78843..79828 (-)	986	Protein_89	FUSC family protein	-
LUZ08_RS00455	map	80356..81114 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LUZ08_RS00460	-	81331..81717 (+)	387	WP_001110179.1	hypothetical protein	-
LUZ08_RS00465	liaF	81732..82433 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LUZ08_RS00470	vraS	82430..83473 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LUZ08_RS00475	vraR	83463..84092 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
LUZ08_RS00480	-	84208..85425 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
LUZ08_RS00485	-	85703..85978 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
LUZ08_RS00490	-	85985..86449 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LUZ08_RS00495	-	86596..86796 (+)	201	WP_000180461.1	DUF1128 family protein	-
LUZ08_RS00500	-	86799..88055 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=637371 LUZ08_RS00470 WP_001017131.1 82430..83473(+) (vraS) [Staphylococcus aureus strain E1174_IV_ST22]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=637371 LUZ08_RS00470 WP_001017131.1 82430..83473(+) (vraS) [Staphylococcus aureus strain E1174_IV_ST22]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1