Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   LUZ03_RS10390 Genome accession   NZ_CP089487
Coordinates   2071367..2072716 (+) Length   449 a.a.
NCBI ID   WP_407301130.1    Uniprot ID   -
Organism   Staphylococcus aureus strain 0220_II_ST5     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2052368..2081131 2071367..2072716 within 0


Gene organization within MGE regions


Location: 2052368..2081131
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LUZ03_RS10285 - 2052368..2054293 (-) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -
  LUZ03_RS10290 - 2054623..2054949 (-) 327 WP_000391495.1 metalloregulator ArsR/SmtB family transcription factor -
  LUZ03_RS10295 - 2055156..2055515 (+) 360 WP_001631039.1 hypothetical protein -
  LUZ03_RS10300 - 2055627..2055965 (-) 339 Protein_1993 recombinase family protein -
  LUZ03_RS10305 - 2055974..2056603 (+) 630 Protein_1994 hypothetical protein -
  LUZ03_RS10310 ccrA 2056790..2058151 (+) 1362 WP_001631036.1 cassette chromosome recombinase CcrA Machinery gene
  LUZ03_RS10315 ccrB 2058148..2059776 (+) 1629 WP_407301129.1 cassette chromosome recombinase CcrB Machinery gene
  LUZ03_RS10320 - 2060277..2060627 (+) 351 WP_061734627.1 SAUGI family uracil-DNA glycosylase inhibitor -
  LUZ03_RS10325 - 2060714..2061025 (+) 312 WP_001631033.1 DUF960 domain-containing protein -
  LUZ03_RS10330 - 2061041..2061544 (+) 504 WP_001631032.1 DUF1643 domain-containing protein -
  LUZ03_RS10335 - 2061559..2061779 (+) 221 Protein_2000 hypothetical protein -
  LUZ03_RS10340 - 2061942..2062352 (+) 411 WP_001631031.1 DUF2871 domain-containing protein -
  LUZ03_RS10345 - 2063024..2063521 (+) 498 WP_001631030.1 GNAT family N-acetyltransferase -
  LUZ03_RS10350 - 2063580..2063798 (+) 219 Protein_2003 IS5/IS1182 family transposase -
  LUZ03_RS10355 - 2063843..2065045 (-) 1203 WP_061731577.1 restriction endonuclease subunit S -
  LUZ03_RS10360 - 2065038..2065181 (-) 144 WP_001631028.1 restriction endonuclease subunit R -
  LUZ03_RS10365 - 2065366..2066166 (-) 801 WP_000749912.1 abortive infection family protein -
  LUZ03_RS10370 - 2066196..2067350 (-) 1155 WP_000912116.1 ATP-binding protein -
  LUZ03_RS10375 - 2067805..2068851 (+) 1047 WP_001042023.1 hypothetical protein -
  LUZ03_RS10380 ssb 2069044..2069340 (+) 297 WP_000273823.1 cassette chromosome ssDNA-binding protein -
  LUZ03_RS10385 cch1 2069340..2071133 (+) 1794 WP_000079473.1 cassette chromosome replicative helicase -
  LUZ03_RS10390 ccrA 2071367..2072716 (+) 1350 WP_407301130.1 cassette chromosome recombinase CcrA Machinery gene
  LUZ03_RS10395 ccrB 2072738..2074366 (+) 1629 WP_001186608.1 cassette chromosome recombinase CcrB Machinery gene
  LUZ03_RS10400 - 2074888..2075238 (+) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  LUZ03_RS10405 - 2075325..2075636 (+) 312 WP_000700851.1 DUF960 family protein -
  LUZ03_RS10410 - 2075651..2076157 (+) 507 WP_001092189.1 DUF1643 domain-containing protein -
  LUZ03_RS10415 - 2076206..2077816 (+) 1611 Protein_2016 IS1182 family transposase -
  LUZ03_RS10420 - 2077807..2078049 (-) 243 Protein_2017 type I restriction enzyme endonuclease domain-containing protein -
  LUZ03_RS10425 - 2078039..2079025 (-) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  LUZ03_RS10430 mecA 2079122..2081131 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52694.26 Da        Isoelectric Point: 9.9199

>NTDB_id=637360 LUZ03_RS10390 WP_407301130.1 2071367..2072716(+) (ccrA) [Staphylococcus aureus strain 0220_II_ST5]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQDRLITTHAPFGYDYH
HGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQTKQTSSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=637360 LUZ03_RS10390 WP_407301130.1 2071367..2072716(+) (ccrA) [Staphylococcus aureus strain 0220_II_ST5]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGATCGATTGATTACAACACATGCACCTTTTGGTTACGATTATCAC
CACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGCCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-250)

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.327

100

0.973
  ccrA Staphylococcus aureus COL

75.278

100

0.753