Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | LUY99_RS10030 | Genome accession | NZ_CP089479 |
| Coordinates | 1967744..1969090 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain 0073_III_ST239 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 1911991..1969090 | 1967744..1969090 | within | 0 |
Gene organization within MGE regions
Location: 1911991..1969090
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LUY99_RS09720 | ccrC | 1911991..1913676 (+) | 1686 | WP_000676600.1 | cassette chromosome recombinase CcrC | - |
| LUY99_RS09725 | tnpA | 1913724..1914209 (+) | 486 | WP_000093392.1 | IS200/IS605 family transposase | - |
| LUY99_RS09730 | - | 1914501..1914839 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| LUY99_RS09735 | - | 1914933..1915244 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| LUY99_RS09740 | - | 1915260..1915766 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| LUY99_RS09745 | - | 1915787..1916104 (+) | 318 | WP_000659046.1 | JAB domain-containing protein | - |
| LUY99_RS09750 | - | 1916223..1917308 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| LUY99_RS09755 | - | 1917305..1919197 (+) | 1893 | Protein_1894 | site-specific integrase | - |
| LUY99_RS09760 | - | 1919204..1919581 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| LUY99_RS09765 | - | 1919732..1920514 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| LUY99_RS09770 | erm(A) | 1920640..1921371 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| LUY99_RS09775 | - | 1921429..1921488 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| LUY99_RS09780 | - | 1921880..1922542 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| LUY99_RS09785 | - | 1922774..1922920 (+) | 147 | Protein_1900 | JAB domain-containing protein | - |
| LUY99_RS09790 | - | 1923090..1923962 (+) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| LUY99_RS09795 | - | 1924019..1924309 (+) | 291 | WP_000065262.1 | hypothetical protein | - |
| LUY99_RS09800 | - | 1924325..1924813 (+) | 489 | WP_000397419.1 | hypothetical protein | - |
| LUY99_RS09805 | - | 1924948..1925475 (+) | 528 | WP_000717928.1 | hypothetical protein | - |
| LUY99_RS09810 | - | 1925538..1925954 (+) | 417 | WP_000941331.1 | hypothetical protein | - |
| LUY99_RS09815 | - | 1926421..1926642 (+) | 222 | WP_001070883.1 | hypothetical protein | - |
| LUY99_RS09820 | - | 1926792..1927358 (+) | 567 | WP_000759939.1 | PepSY domain-containing protein | - |
| LUY99_RS09825 | - | 1927438..1929651 (-) | 2214 | Protein_1908 | type I restriction endonuclease subunit R | - |
| LUY99_RS09830 | - | 1929713..1930387 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| LUY99_RS09835 | - | 1930670..1932016 (+) | 1347 | WP_000163428.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| LUY99_RS09840 | merR | 1932316..1932723 (+) | 408 | WP_025175377.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| LUY99_RS09845 | - | 1932740..1933225 (+) | 486 | WP_000746202.1 | TlpA disulfide reductase family protein | - |
| LUY99_RS09850 | - | 1933222..1933902 (+) | 681 | WP_000010352.1 | cytochrome c biogenesis CcdA family protein | - |
| LUY99_RS09855 | merT | 1933990..1934376 (+) | 387 | WP_001794630.1 | mercuric transport protein MerT | - |
| LUY99_RS09860 | merA | 1934434..1936077 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| LUY99_RS09865 | merB | 1936159..1936809 (+) | 651 | WP_000790333.1 | organomercurial lyase MerB | - |
| LUY99_RS09870 | - | 1937004..1937519 (-) | 516 | WP_000377078.1 | hypothetical protein | - |
| LUY99_RS09875 | - | 1937638..1938312 (-) | 675 | WP_001105988.1 | IS6-like element IS257 family transposase | - |
| LUY99_RS09880 | - | 1938745..1939077 (-) | 333 | WP_001803416.1 | DUF3021 domain-containing protein | - |
| LUY99_RS09885 | - | 1939106..1939348 (-) | 243 | WP_001803415.1 | LytTR family DNA-binding domain-containing protein | - |
| LUY99_RS09890 | - | 1939480..1940154 (-) | 675 | WP_001106055.1 | IS6-like element IS257 family transposase | - |
| LUY99_RS09895 | tet(K) | 1940351..1941730 (+) | 1380 | WP_000492283.1 | tetracycline efflux MFS transporter Tet(K) | - |
| LUY99_RS09900 | mobV | 1941919..1943160 (+) | 1242 | WP_000122374.1 | MobV family relaxase | - |
| LUY99_RS09905 | - | 1943687..1944641 (+) | 955 | Protein_1924 | replication initiation factor domain-containing protein | - |
| LUY99_RS09910 | - | 1944730..1945404 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| LUY99_RS09915 | - | 1945488..1945829 (+) | 342 | WP_001797647.1 | hydroxymethylglutaryl-CoA synthase | - |
| LUY99_RS09920 | - | 1946666..1947409 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| LUY99_RS09925 | - | 1947506..1947934 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| LUY99_RS09930 | mecA | 1947980..1949989 (-) | 2010 | WP_078056052.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| LUY99_RS09935 | mecR1 | 1950086..1951843 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| LUY99_RS09940 | mecI | 1951843..1952214 (+) | 372 | Protein_1931 | mecA-type methicillin resistance repressor MecI | - |
| LUY99_RS09945 | psm-mec | 1952299..1952367 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| LUY99_RS09950 | - | 1952726..1953835 (+) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| LUY99_RS09955 | cstB | 1953949..1955283 (-) | 1335 | Protein_1934 | persulfide dioxygenase-sulfurtransferase CstB | - |
| LUY99_RS09960 | - | 1955315..1956379 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| LUY99_RS09965 | cstR | 1956515..1956775 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| LUY99_RS09970 | - | 1956775..1957413 (+) | 639 | Protein_1937 | sulfite exporter TauE/SafE family protein | - |
| LUY99_RS09975 | - | 1957687..1958304 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| LUY99_RS09980 | - | 1958385..1960799 (-) | 2415 | WP_000378486.1 | cadmium-translocating P-type ATPase CadA | - |
| LUY99_RS09985 | - | 1960792..1961157 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| LUY99_RS09990 | - | 1961343..1961720 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| LUY99_RS09995 | - | 1961727..1963619 (-) | 1893 | WP_014532403.1 | site-specific integrase | - |
| LUY99_RS10000 | - | 1963814..1964137 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| LUY99_RS10005 | - | 1964130..1964336 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| LUY99_RS10010 | - | 1964338..1964859 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| LUY99_RS10015 | - | 1964878..1965189 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| LUY99_RS10020 | - | 1965274..1965624 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| LUY99_RS10025 | ccrB | 1966095..1967723 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| LUY99_RS10030 | ccrA | 1967744..1969090 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=637182 LUY99_RS10030 WP_000816499.1 1967744..1969090(-) (ccrA) [Staphylococcus aureus strain 0073_III_ST239]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=637182 LUY99_RS10030 WP_000816499.1 1967744..1969090(-) (ccrA) [Staphylococcus aureus strain 0073_III_ST239]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |