Detailed information NTG0637171

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LUY99_RS04335
• Genome accession: NZ_CP089479
• Coordinates: 876849..877892 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 0073_III_ST239
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 871849..882892

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LUY99_RS04305	-	872267..873523 (-)	1257	WP_001795438.1	aminopeptidase	-
LUY99_RS04310	-	873526..873726 (-)	201	WP_000180461.1	DUF1128 family protein	-
LUY99_RS04315	-	873873..874337 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LUY99_RS04320	-	874344..874619 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
LUY99_RS04325	-	874897..876114 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
LUY99_RS04330	vraR	876230..876859 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
LUY99_RS04335	vraS	876849..877892 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LUY99_RS04340	liaF	877889..878590 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LUY99_RS04345	-	878605..878991 (-)	387	WP_001110179.1	hypothetical protein	-
LUY99_RS04350	map	879208..879966 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LUY99_RS04355	-	880438..881424 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
LUY99_RS04360	-	881855..882268 (-)	414	WP_001549145.1	hypothetical protein	-
LUY99_RS04365	-	882297..882407 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=637171 LUY99_RS04335 WP_001017131.1 876849..877892(-) (vraS) [Staphylococcus aureus strain 0073_III_ST239]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=637171 LUY99_RS04335 WP_001017131.1 876849..877892(-) (vraS) [Staphylococcus aureus strain 0073_III_ST239]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1