Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   LUY90_RS10310 Genome accession   NZ_CP089477
Coordinates   2056533..2057894 (+) Length   453 a.a.
NCBI ID   WP_001631036.1    Uniprot ID   -
Organism   Staphylococcus aureus strain 0.1345_II_ST5     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2052111..2080874 2056533..2057894 within 0


Gene organization within MGE regions


Location: 2052111..2080874
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LUY90_RS10285 - 2052111..2054036 (-) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -
  LUY90_RS10290 - 2054366..2054692 (-) 327 WP_000391495.1 metalloregulator ArsR/SmtB family transcription factor -
  LUY90_RS10295 - 2054899..2055258 (+) 360 WP_001631039.1 hypothetical protein -
  LUY90_RS10300 - 2055370..2055708 (-) 339 Protein_1993 recombinase family protein -
  LUY90_RS10305 - 2055717..2056346 (+) 630 Protein_1994 hypothetical protein -
  LUY90_RS10310 ccrA 2056533..2057894 (+) 1362 WP_001631036.1 cassette chromosome recombinase CcrA Machinery gene
  LUY90_RS10315 ccrB 2057891..2059519 (+) 1629 WP_407301129.1 cassette chromosome recombinase CcrB Machinery gene
  LUY90_RS10320 - 2060020..2060370 (+) 351 WP_061734627.1 SAUGI family uracil-DNA glycosylase inhibitor -
  LUY90_RS10325 - 2060457..2060768 (+) 312 WP_001631033.1 DUF960 domain-containing protein -
  LUY90_RS10330 - 2060784..2061287 (+) 504 WP_001631032.1 DUF1643 domain-containing protein -
  LUY90_RS10335 - 2061302..2061522 (+) 221 Protein_2000 hypothetical protein -
  LUY90_RS10340 - 2061685..2062095 (+) 411 WP_001631031.1 DUF2871 domain-containing protein -
  LUY90_RS10345 - 2062767..2063264 (+) 498 WP_001631030.1 GNAT family N-acetyltransferase -
  LUY90_RS10350 - 2063323..2063541 (+) 219 Protein_2003 IS5/IS1182 family transposase -
  LUY90_RS10355 - 2063586..2064788 (-) 1203 WP_061731577.1 restriction endonuclease subunit S -
  LUY90_RS10360 - 2064781..2064924 (-) 144 WP_001631028.1 restriction endonuclease subunit R -
  LUY90_RS10365 - 2065109..2065909 (-) 801 WP_000749912.1 abortive infection family protein -
  LUY90_RS10370 - 2065939..2067093 (-) 1155 WP_000912116.1 ATP-binding protein -
  LUY90_RS10375 - 2067548..2068594 (+) 1047 WP_001042023.1 hypothetical protein -
  LUY90_RS10380 ssb 2068787..2069083 (+) 297 WP_000273823.1 cassette chromosome ssDNA-binding protein -
  LUY90_RS10385 cch1 2069083..2070876 (+) 1794 WP_000079473.1 cassette chromosome replicative helicase -
  LUY90_RS10390 ccrA 2071110..2072459 (+) 1350 WP_407301130.1 cassette chromosome recombinase CcrA Machinery gene
  LUY90_RS10395 ccrB 2072481..2074109 (+) 1629 WP_001186608.1 cassette chromosome recombinase CcrB Machinery gene
  LUY90_RS10400 - 2074631..2074981 (+) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  LUY90_RS10405 - 2075068..2075379 (+) 312 WP_000700851.1 DUF960 family protein -
  LUY90_RS10410 - 2075394..2075900 (+) 507 WP_001092189.1 DUF1643 domain-containing protein -
  LUY90_RS10415 - 2075949..2077559 (+) 1611 Protein_2016 IS1182 family transposase -
  LUY90_RS10420 - 2077550..2077792 (-) 243 Protein_2017 type I restriction enzyme endonuclease domain-containing protein -
  LUY90_RS10425 - 2077782..2078768 (-) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  LUY90_RS10430 mecA 2078865..2080874 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 53316.45 Da        Isoelectric Point: 9.8596

>NTDB_id=637136 LUY90_RS10310 WP_001631036.1 2056533..2057894(+) (ccrA) [Staphylococcus aureus strain 0.1345_II_ST5]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=637136 LUY90_RS10310 WP_001631036.1 2056533..2057894(+) (ccrA) [Staphylococcus aureus strain 0.1345_II_ST5]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(168-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

54.628

97.792

0.534
  ccrA Staphylococcus aureus N315

50.564

97.792

0.494